pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-539Research ArticleОБЗОРЫREVIEWSТочки приложения противовирусной терапии хронической HBV-инфекции у беременныхAntiviral therapy for chronic HBV during pregnancyБогомоловП. О.BogomolovP. O.hepatology@monikiweb.ruМациевичМ. В.MatsievichM. V.noemail@neicon.ruВоронковаН. В.VoronkovaN. V.noemail@neicon.ruКузьминаО. С.KuzminaO. S.noemail@neicon.ruМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow’s regional research clinical institute n.a. M.F. VladimirskiyRussian FederationПодольская городская клиническая больницаРоссияPodolsk clinical hospitalRussian Federation201528092015032225Copyright © Богомолов П.О., Мациевич М.В., Воронкова Н.В., Кузьмина О.С., 20152015Богомолов П.О., Мациевич М.В., Воронкова Н.В., Кузьмина О.С.Bogomolov P.O., Matsievich M.V., Voronkova N.V., Kuzmina O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/539

Лечение хронического гепатита В во время беременности - крайне сложная задача. Несмотря на иммунопрофилактику, значительная доля детей, рожденных от матерей с высокой виремией, оказывается инфицирована вирусом гепатита В. Накопленные данные позволяют предположить, что противовирусная терапия в III триместре беременности является эффективным вмешательством при неудачной иммунопрофилактике. Для минимизации воздействия на плод аналогов нуклеози(ти)тов, противовирусная терапия во время беременности должна назначаться женщинам с высоким риском прогрессирования заболевания и/или декомпенсации инфекции. Полученные на сегодняшний день данные о безопасности свидетельствуют о том, что телбивудин и тенофовир могут использоваться во время беременности. В то же время проведение противовирусной терапии здесь требует тщательной оценки рисков и пользы.

Chronic hepatitis B treatment during pregnancy is an extremely difficult task. Regardless immunoprophylaxis a significant proportion of children, born of mothers with high viraemia, is infect-ed with hepatitis B virus. Accumulating data suggests that antiviral therapy is an effective therapy procedure in III trimester for immunoprophylaxis failed. To minimize the counterparts of nucleosi(ti)des impact on embryo antiviral therapy during pregnancy should be prescribed to women at high risk of progressive disease and/ or hepatic decompensation. Currently received safety data gives evidence of telbivudin and tenofovir may be taken during pregnancy. At the same time antiviral therapy requires a careful assessment of risk-benefit ratio.

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The authors declare that there are no conflicts of interest present.