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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-565</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Фармаконутрициология некрахмальных полисахаридов</article-title><trans-title-group xml:lang="en"><trans-title>Pharmaconutritiology of non-starch polysaccharides</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хотимченко</surname><given-names>Р. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Khotimchenko</surname><given-names>R. Yu.</given-names></name></name-alternatives><email xlink:type="simple">yukhotimchenko.ry@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт биологии моря им. А.В.Жирмунского ДВО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2015</year></pub-date><volume>0</volume><issue>2</issue><fpage>5</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хотимченко Р.Ю., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Хотимченко Р.Ю.</copyright-holder><copyright-holder xml:lang="en">Khotimchenko R.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/565">https://www.tmj-vgmu.ru/jour/article/view/565</self-uri><abstract><p>Обзор литературы, посвященный химической структуре, физико-химическим свойствам, фармакологической активности и пищевой ценности некрахмальных полисахаридов, представляющих одну из самых сложных и разнообразных в химическом отношении групп органических соединений. Описаны физиологические эффекты и механизмы действия некрахмальных полисахаридов в организме животных и человека. Показана роль этих соединений в предупреждении общественно-значимых заболеваний, таких как сердечно-сосудистые болезни, ожирение, диабет, кишечные дисбиозы и колоректальный рак. Некрахмальные полисахариды подготавливают основу для создания новых функциональных продуктов, биологически активных добавок к пище и фармацевтических субстанций.</p></abstract><trans-abstract xml:lang="en"><p>Review of the literature devoted to the chemical structure, physicochemical properties, pharmacological activity and the nutritional value of non-starch polysaccharides, representing one of the most complex and diverse chemically groups of organic compounds. Physiological effects and mechanisms of action of non-starch polysaccharides in animals and humans are described. The role of these compounds in the prevention of socially significant diseases, such as cardiovascular disease, obesity, diabetes, intestinal dysbiosis, and colorectal cancer. Non-starch polysaccharides are the basis for the creation of new functional foods, dietary supplements and pharmaceutical substances.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пищевые волокна</kwd><kwd>короткоцепочные жирные кислоты</kwd><kwd>фармакологические эффекты</kwd><kwd>функциональные пищевые продукты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dietary fibers</kwd><kwd>short-chain fatty acids</kwd><kwd>pharmaceutical effects</kwd><kwd>functional foods</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Оводов Ю.С. Современные представления о пектиновых веществах // Биоорганич. химия. 2009. Т. 35, № 3. С. 293-310.</mixed-citation><mixed-citation xml:lang="en">Оводов Ю.С. Современные представления о пектиновых веществах // Биоорганич. химия. 2009. Т. 35, № 3. С. 293-310.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Хотимченко М.Ю. Фармаконутрициология альгинатов. Владивосток: Дальнаука, 2009. 170 с.</mixed-citation><mixed-citation xml:lang="en">Хотимченко М.Ю. Фармаконутрициология альгинатов. Владивосток: Дальнаука, 2009. 170 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Хотимченко Ю.С. Противоопухолевые свойства некрахмальных полисахаридов: фукоиданы, хитозаны // Биол. моря. 2010. Т. 36, № 5. С. 319-328.</mixed-citation><mixed-citation xml:lang="en">Хотимченко Ю.С. Противоопухолевые свойства некрахмальных полисахаридов: фукоиданы, хитозаны // Биол. моря. 2010. Т. 36, № 5. С. 319-328.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Хотимченко Ю.С. Противоопухолевые свойства некрахмальных полисахаридов: каррагинаны, альгинаты, пектины // Биол. моря. 2010. Т. 36, № 6. С. 399-409.</mixed-citation><mixed-citation xml:lang="en">Хотимченко Ю.С. Противоопухолевые свойства некрахмальных полисахаридов: каррагинаны, альгинаты, пектины // Биол. моря. 2010. Т. 36, № 6. С. 399-409.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Хотимченко Ю.С., Ермак И.М., Бедняк А.Е. [и др.] Фармакология некрахмальных полисахаридов // Вестник ДВО РАН. 2005. № 1. С. 72-81.</mixed-citation><mixed-citation xml:lang="en">Хотимченко Ю.С., Ермак И.М., Бедняк А.Е. [и др.] Фармакология некрахмальных полисахаридов // Вестник ДВО РАН. 2005. № 1. С. 72-81.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Akin H., Tözün N. Diet, microbiota, and colorectal cancer // J. Clin. Gastroenterol. 2014. Vol. 48, Suppl. 1. P. S67-S69.</mixed-citation><mixed-citation xml:lang="en">Akin H., Tözün N. Diet, microbiota, and colorectal cancer // J. Clin. Gastroenterol. 2014. Vol. 48, Suppl. 1. P. S67-S69.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Alex S., Lange K., Amolo T. [et al.] Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ // Mol. Cell. Biol. 2013. Vol. 33. P. 1303-1316.</mixed-citation><mixed-citation xml:lang="en">Alex S., Lange K., Amolo T. [et al.] Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ // Mol. Cell. Biol. 2013. Vol. 33. P. 1303-1316.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson J.W., Randles K.M., Kendall C.W.C., Jenkins D.J.A. Carbohydrate and fiber recommendations for individuals with diabetes: A quantitative assessment and meta-analysis of the evidence // J. Am. Coll. Nutr. 2004. Vol. 23. P. 5-17.</mixed-citation><mixed-citation xml:lang="en">Anderson J.W., Randles K.M., Kendall C.W.C., Jenkins D.J.A. Carbohydrate and fiber recommendations for individuals with diabetes: A quantitative assessment and meta-analysis of the evidence // J. Am. Coll. Nutr. 2004. Vol. 23. P. 5-17.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bingham S.A., Luben R., Day N.E. [et al.] Plant polysaccharides, meat and colorectal cancer // IARC Sci. Publ. 2002. Vol. 156. P. 349-352.</mixed-citation><mixed-citation xml:lang="en">Bingham S.A., Luben R., Day N.E. [et al.] Plant polysaccharides, meat and colorectal cancer // IARC Sci. Publ. 2002. Vol. 156. P. 349-352.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Brockman D.A., Chen X., Gallaher D.D. Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats // Nutr. Metab. (Lond.). 2012. Vol. 9, No. 1:100. doi: 10.1186/1743-7075-9-100.</mixed-citation><mixed-citation xml:lang="en">Brockman D.A., Chen X., Gallaher D.D. Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats // Nutr. Metab. (Lond.). 2012. Vol. 9, No. 1:100. doi: 10.1186/1743-7075-9-100.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Buttriss J.L., Stokes C.S. Dietary fiber and health: An overview // Br. Nutr. Found. Nutr. Bull. 2008. Vol. 33. P. 186-200.</mixed-citation><mixed-citation xml:lang="en">Buttriss J.L., Stokes C.S. Dietary fiber and health: An overview // Br. Nutr. Found. Nutr. Bull. 2008. Vol. 33. P. 186-200.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Carlson J.J., Eisenmann J.C., Norman G.J. [et al.] Dietary fiber and nutrient density are inversely associated with the metabolic syndrome in US adolescents // J. Am. Diet. Assoc. 2011. Vol. 111. P. 1688-1695.</mixed-citation><mixed-citation xml:lang="en">Carlson J.J., Eisenmann J.C., Norman G.J. [et al.] Dietary fiber and nutrient density are inversely associated with the metabolic syndrome in US adolescents // J. Am. Diet. Assoc. 2011. Vol. 111. P. 1688-1695.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Collén P.N., Lemoine M., Daniellou R. [et al.] Enzymatic degradation of κ-carrageenan in aqueous solution // Biomacromolecules. 2009. Vol. 10. P. 1757-1767.</mixed-citation><mixed-citation xml:lang="en">Collén P.N., Lemoine M., Daniellou R. [et al.] Enzymatic degradation of κ-carrageenan in aqueous solution // Biomacromolecules. 2009. Vol. 10. P. 1757-1767.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings J.H., Stephen A.M. Carbohydrate terminology and classification // Eur. J. Clin. Nutr. 2007. Vol. 61. P. 5-18.</mixed-citation><mixed-citation xml:lang="en">Cummings J.H., Stephen A.M. Carbohydrate terminology and classification // Eur. J. Clin. Nutr. 2007. Vol. 61. P. 5-18.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Eliz I., Weil E., Wilk B. Integrative medicine and role of modified citrus pectin/alginates in heavy metal chelation and detoxification - five case reports // Forsch Komplementarmed. 2007. Vol. 14. Р. 358-364</mixed-citation><mixed-citation xml:lang="en">Eliz I., Weil E., Wilk B. Integrative medicine and role of modified citrus pectin/alginates in heavy metal chelation and detoxification - five case reports // Forsch Komplementarmed. 2007. Vol. 14. Р. 358-364</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez R., Sacristan J., Mijangos C. Sol/gel transition of aqueous alginate solutions induced by Fe2+ cations / / Macromol. Chem. Phys. 2010. Vol. 211. P. 1254-1260.</mixed-citation><mixed-citation xml:lang="en">Hernandez R., Sacristan J., Mijangos C. Sol/gel transition of aqueous alginate solutions induced by Fe2+ cations / / Macromol. Chem. Phys. 2010. Vol. 211. P. 1254-1260.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Howe G.R., Benito E., Castelleto R. [et al.] Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies // J. Natl. Cancer Inst. 1992. Vol. 84. P. 1887-1896.</mixed-citation><mixed-citation xml:lang="en">Howe G.R., Benito E., Castelleto R. [et al.] Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies // J. Natl. Cancer Inst. 1992. Vol. 84. P. 1887-1896.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ikekawa T. Beneficial effects of edible and medicinal mushrooms in health care // Int. J. Med. Mushrooms. 2001. Vol. 3. P. 291-298.</mixed-citation><mixed-citation xml:lang="en">Ikekawa T. Beneficial effects of edible and medicinal mushrooms in health care // Int. J. Med. Mushrooms. 2001. Vol. 3. P. 291-298.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsdottir G., Nilsson U., Blanco N. [et al.] Effects of soluble and insoluble fractions from bilberries, black currants, and raspberries on short-chain fatty acid formation, anthocyanin excretion, and cholesterol in rats // J. Agric. Food Chem. 2014. Vol. 62. P. 4359-4368.</mixed-citation><mixed-citation xml:lang="en">Jakobsdottir G., Nilsson U., Blanco N. [et al.] Effects of soluble and insoluble fractions from bilberries, black currants, and raspberries on short-chain fatty acid formation, anthocyanin excretion, and cholesterol in rats // J. Agric. Food Chem. 2014. Vol. 62. P. 4359-4368.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jones J.M. CODEX-aligned dietary fiber definitions help to bridge the “fiber gap” // Nutr. J. 2014. 13:34. doi: 10.1186/14752891-13-34.</mixed-citation><mixed-citation xml:lang="en">Jones J.M. CODEX-aligned dietary fiber definitions help to bridge the “fiber gap” // Nutr. J. 2014. 13:34. doi: 10.1186/14752891-13-34.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kalkwarf H.J., Bell R.C., Khoury J.C. [et al.] Dietary fiber intakes and insulin requirements in pregnant women with type 1 diabetes // J. Am. Diet Assoc. 2001. Vol. 101. P. 305-310.</mixed-citation><mixed-citation xml:lang="en">Kalkwarf H.J., Bell R.C., Khoury J.C. [et al.] Dietary fiber intakes and insulin requirements in pregnant women with type 1 diabetes // J. Am. Diet Assoc. 2001. Vol. 101. P. 305-310.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M., Khozhaenko E., Kolenchenko E., Khotimchenko Y. Influence of pectin substances on strontium removal in rats // Int. J. Pharm. Pharmac. Sci. 2012. Vol. 4. P. 269-273.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M., Khozhaenko E., Kolenchenko E., Khotimchenko Y. Influence of pectin substances on strontium removal in rats // Int. J. Pharm. Pharmac. Sci. 2012. Vol. 4. P. 269-273.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. Zinc-binding activity of different pectin compounds in aqueous solutions // J. Colloid Interface Sci. 2008. Vol. 323. P. 216-222.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. Zinc-binding activity of different pectin compounds in aqueous solutions // J. Colloid Interface Sci. 2008. Vol. 323. P. 216-222.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. [et al.] Cerium binding activity of different pectin compounds in aqueous solutions // Colloid. Surf. B. 2010. Vol. 77. P. 104-110.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. [et al.] Cerium binding activity of different pectin compounds in aqueous solutions // Colloid. Surf. B. 2010. Vol. 77. P. 104-110.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M.Y., Podkorytova E.A., Kovalev V.V. [et al.] Removal of cesium from aqueous solutions by sodium and calcium alginates // J. Environ. Sci. Technol. 2014. Vol. 7. P. 30-43.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M.Y., Podkorytova E.A., Kovalev V.V. [et al.] Removal of cesium from aqueous solutions by sodium and calcium alginates // J. Environ. Sci. Technol. 2014. Vol. 7. P. 30-43.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M., Sergushchenko I., Khotimchenko Y. The effects of low-esterified pectin on lead-induced thyroid injury in rats // Environ. Toxicol. Pharmacol. 2004. Vol. 17. P. 67-71.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M., Sergushchenko I., Khotimchenko Y. The effects of low-esterified pectin on lead-induced thyroid injury in rats // Environ. Toxicol. Pharmacol. 2004. Vol. 17. P. 67-71.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kim Y., Je Y. Dietary fiber intake and total mortality: a meta-analysis of prospective cohort studies // Am. J. Epidemiol. 2014. Vol. 180. P. 565-573.</mixed-citation><mixed-citation xml:lang="en">Kim Y., Je Y. Dietary fiber intake and total mortality: a meta-analysis of prospective cohort studies // Am. J. Epidemiol. 2014. Vol. 180. P. 565-573.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kranz S., Brauchla M., Slavin J.L., Miller K.B. What do we know about dietary fiber intake in children and health? The effects of fiber intake on constipation, obesity, and diabetes in children // Adv. Nutr. 2012. Vol. 3. P. 47-53.</mixed-citation><mixed-citation xml:lang="en">Kranz S., Brauchla M., Slavin J.L., Miller K.B. What do we know about dietary fiber intake in children and health? The effects of fiber intake on constipation, obesity, and diabetes in children // Adv. Nutr. 2012. Vol. 3. P. 47-53.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar M., Nagpal R., Verma V. [et al.] Probiotic metabolites as epigenetic targets in the prevention of colon cancer // Nutr. Rev. 2013. Vol. 71. P. 23-34.</mixed-citation><mixed-citation xml:lang="en">Kumar M., Nagpal R., Verma V. [et al.] Probiotic metabolites as epigenetic targets in the prevention of colon cancer // Nutr. Rev. 2013. Vol. 71. P. 23-34.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar V., Sinha A.K., Makkar H.P. [et al.] Dietary roles of nonstarch polysaccharides in human nutrition: a review // Crit. Rev. Food Sci. Nutr. 2012. Vol. 52. P. 899-935.</mixed-citation><mixed-citation xml:lang="en">Kumar V., Sinha A.K., Makkar H.P. [et al.] Dietary roles of nonstarch polysaccharides in human nutrition: a review // Crit. Rev. Food Sci. Nutr. 2012. Vol. 52. P. 899-935.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lazaridou, A., Biliaderis, C.G., Izydorczyk, M.S. Molecular size effects on rheological properties of oat β-glucans in solutions and gels // Food Hydrocolloid. 2003. Vol. 17. P. 693-712.</mixed-citation><mixed-citation xml:lang="en">Lazaridou, A., Biliaderis, C.G., Izydorczyk, M.S. Molecular size effects on rheological properties of oat β-glucans in solutions and gels // Food Hydrocolloid. 2003. Vol. 17. P. 693-712.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Levitskaia T.G., Creim J.A., Curry T.L. [et al.] Biomaterials for the decorporation of 85Sr in the rat // Health Phys. 2010. Vol. 99. P. 393-400.</mixed-citation><mixed-citation xml:lang="en">Levitskaia T.G., Creim J.A., Curry T.L. [et al.] Biomaterials for the decorporation of 85Sr in the rat // Health Phys. 2010. Vol. 99. P. 393-400.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mansour A., Hosseini S., Larijani B. [et al.] Nutrients related to GLP1 secretory responses // Nutrition. 2013. Vol. 29. P. 813-820.</mixed-citation><mixed-citation xml:lang="en">Mansour A., Hosseini S., Larijani B. [et al.] Nutrients related to GLP1 secretory responses // Nutrition. 2013. Vol. 29. P. 813-820.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta N., Ahlawat S.S., Sharma D.P., Dabur R.S. Novel trends in development of dietary fiber rich meat products-a critical review // J. Food Sci. Technol. 2015. Vol. 52. P. 633-647.</mixed-citation><mixed-citation xml:lang="en">Mehta N., Ahlawat S.S., Sharma D.P., Dabur R.S. Novel trends in development of dietary fiber rich meat products-a critical review // J. Food Sci. Technol. 2015. Vol. 52. P. 633-647.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer D. Health benefits of prebiotic fibers // Adv. Food Nutr. Res. 2015. Vol. 74. P. 47-91.</mixed-citation><mixed-citation xml:lang="en">Meyer D. Health benefits of prebiotic fibers // Adv. Food Nutr. Res. 2015. Vol. 74. P. 47-91.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Nesterenko VB., Nesterenko A.V 13. Decorporation of Chernobyl radionuclides // Ann. N.Y. Acad. Sci. 2009. No. 1181. P. 303-310.</mixed-citation><mixed-citation xml:lang="en">Nesterenko VB., Nesterenko A.V 13. Decorporation of Chernobyl radionuclides // Ann. N.Y. Acad. Sci. 2009. No. 1181. P. 303-310.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Prajapati V.D., Jani G.K., Moradiya N.G. [et al.] Galactomannan: a versatile biodegradable seed polysaccharide // Int. J. Biol. Macromol. 2013. Vol. 60. P. 83-92.</mixed-citation><mixed-citation xml:lang="en">Prajapati V.D., Jani G.K., Moradiya N.G. [et al.] Galactomannan: a versatile biodegradable seed polysaccharide // Int. J. Biol. Macromol. 2013. Vol. 60. P. 83-92.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Qiao Z., Koizumi Y., Zhang M. [et al.] Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells // Biosci. Biotechnol. Biochem. 2012. Vol. 76. P. 1877-1883.</mixed-citation><mixed-citation xml:lang="en">Qiao Z., Koizumi Y., Zhang M. [et al.] Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells // Biosci. Biotechnol. Biochem. 2012. Vol. 76. P. 1877-1883.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez R., Jimenez A., Bolanos J.F. [et al.] Dietary fiber from vegetable products as source of functional ingredients // Trends Food Sci. Technol. 2006. Vol. 17. P. 3-15.</mixed-citation><mixed-citation xml:lang="en">Rodriguez R., Jimenez A., Bolanos J.F. [et al.] Dietary fiber from vegetable products as source of functional ingredients // Trends Food Sci. Technol. 2006. Vol. 17. P. 3-15.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Schulze M.B., Liu S. Rimm E.B. [et al.] Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women // Am. J. Clin. Nutr. 2004. Vol. 80. P. 348-356.</mixed-citation><mixed-citation xml:lang="en">Schulze M.B., Liu S. Rimm E.B. [et al.] Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women // Am. J. Clin. Nutr. 2004. Vol. 80. P. 348-356.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz B., Hadar Y. Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer // Ann. Transl. Med. 2014. doi: 10.3978/j. issn.2305-5839.2014.01.03.</mixed-citation><mixed-citation xml:lang="en">Schwartz B., Hadar Y. Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer // Ann. Transl. Med. 2014. doi: 10.3978/j. issn.2305-5839.2014.01.03.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Scott K.P., Duncan S.H., Flint H.J. Dietary fiber and the gut microbiota // Nutr. Bull. 2008. Vol. 33. P. 201-211.</mixed-citation><mixed-citation xml:lang="en">Scott K.P., Duncan S.H., Flint H.J. Dietary fiber and the gut microbiota // Nutr. Bull. 2008. Vol. 33. P. 201-211.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Song M., Garrett W.S., Chan A.T. Nutrients, foods, and colorectal cancer prevention // Gastroenterology. 2015. pii: S0016-5085(15)00011-6. doi: 0.1053/j.gastro.2014.12.035.</mixed-citation><mixed-citation xml:lang="en">Song M., Garrett W.S., Chan A.T. Nutrients, foods, and colorectal cancer prevention // Gastroenterology. 2015. pii: S0016-5085(15)00011-6. doi: 0.1053/j.gastro.2014.12.035.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Thiengwilboonwong S., Chongsuwat R., Temcharoen P. [et al.] Efficacy of dietary modification following the National Cholesterol Education Program (NCEP) recommendation on lipid profiles among hyperlipidemia subjects // J. Med. Assoc. Thai. 2013. Vol. 96. P. 1257-1267.</mixed-citation><mixed-citation xml:lang="en">Thiengwilboonwong S., Chongsuwat R., Temcharoen P. [et al.] Efficacy of dietary modification following the National Cholesterol Education Program (NCEP) recommendation on lipid profiles among hyperlipidemia subjects // J. Med. Assoc. Thai. 2013. Vol. 96. P. 1257-1267.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tsuda T. Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1secretion // Mol. Nutr. Food Res. 2015. doi: 10.1002/mnfr.201400871.</mixed-citation><mixed-citation xml:lang="en">Tsuda T. Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1secretion // Mol. Nutr. Food Res. 2015. doi: 10.1002/mnfr.201400871.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Q., Ellis P.R. Oat β-glucan: physico-chemical characteristics in relation to its blood-glucose and cholesterol-lowering properties // Br. J. Nutr. 2014. Vol. 112. P. S4-S13.</mixed-citation><mixed-citation xml:lang="en">Wang Q., Ellis P.R. Oat β-glucan: physico-chemical characteristics in relation to its blood-glucose and cholesterol-lowering properties // Br. J. Nutr. 2014. Vol. 112. P. S4-S13.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wong S.M., Wong K.K., Chiu L.C.M., Cheung P.C.K. Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction // Carbohydr. Polym. 2007. Vol. 68. P. 206-217.</mixed-citation><mixed-citation xml:lang="en">Wong S.M., Wong K.K., Chiu L.C.M., Cheung P.C.K. Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction // Carbohydr. Polym. 2007. Vol. 68. P. 206-217.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Younes I., Rinaudo M. Chitin and chitosan preparation from marine sources. Structure, properties and applications // Mar. Drugs. 2015. Vol. 13. P. 1133-1174.</mixed-citation><mixed-citation xml:lang="en">Younes I., Rinaudo M. Chitin and chitosan preparation from marine sources. Structure, properties and applications // Mar. Drugs. 2015. Vol. 13. P. 1133-1174.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang M., Chiu L.C., Cheung P.C., Ooi V.E. Growth inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: Cell-cycle arrest and apoptosis induction // Oncol. Rep. 2006. Vol. 15. P. 637-643.</mixed-citation><mixed-citation xml:lang="en">Zhang M., Chiu L.C., Cheung P.C., Ooi V.E. Growth inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: Cell-cycle arrest and apoptosis induction // Oncol. Rep. 2006. Vol. 15. P. 637-643.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng X., Li L., Wang X. Molecular characterization of arabinoxylans from hull-less barley milling fractionsles // Molecules.</mixed-citation><mixed-citation xml:lang="en">Zheng X., Li L., Wang X. Molecular characterization of arabinoxylans from hull-less barley milling fractionsles // Molecules.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
