pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-622Research ArticleОБЗОРЫREVIEWSОсобенности эпидемиологии ВИЧ-инфекции, сочетанной с сифилисомSpecific of the HIV-infection epidemiology, combined with syphilisТурсуновР. А.TursunovR. A.trustam.art@mail.ruТаджикский государственный медицинский университет им. Абуали ибни СиноРоссияAbuali ibni Sino Tajik State Medical UniversityRussian Federation201428122014042628Copyright © Турсунов Р.А., 20142014Турсунов Р.А.Tursunov R.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/622

Обзор литературы, посвященный особенностям коинфекции ВИЧ/сифилис. С началом третьего тысячелетия частота инфекций, передаваемых половым путем, на фоне очевидной стагнации пандемического процесса ВИЧ-инфекции, в мире имеет тенденцию к нарастанию, а некоторые из инфекций - в частности сифилис - возрождаются. Коинфекция ВИЧ/сифилис в эпидемическом плане представляет сложную и опасную комбинацию: сифилис значительно увеличивает риск заражения ВИЧ, и ВИЧ-инфекция может изменить естественный ход эпидемии сифилиса. Но несмотря на значительный прогресс в изучении коинфекции ВИЧ/сифилис до сих пор дискутабельным остается вопрос о влиянии сифилиса на прогрессирование ВИЧ-инфекции. Из-за высоких темпов коинфекции ранняя диагностика сифилиса у ВИЧ-инфицированных пациентов требует усилий по улучшению профилактических и противоэпидемических мер как для уменьшения бремени сифилиса, так и риска полового пути передачи ВИЧ-инфекции.

Literature review devoted to the specific of co-infection of HIV/syphilis. Since the beginning of the third millennium, the frequency sexually-transmitted infections, on the background of apparent stagnation of HIV infection pandemic process, in the world have tends to increase, and for some infections - especially syphilis - to revive. HIV/syphilis co-infection in epidemic terms is the complicated and dangerous combination: Syphilis significantly increase the risk of HIV infection and HIV may affect the natural course of the syphilis epidemic. However, despite the significant progress in the study of HIV/syphilis co-infection the question of influence of syphilis on the progression of HIV infection is still debated. Because of the high rates of co-infection, early diagnosis of syphilis in HIV-infected patients require to improve the preventive and antiepidemic measures for the reducing of the burden of syphilis, and for the risk of sexual transmission of HIV

инфекциипередающиеся половым путемкоинфекция ВИЧ/сифилисsexually-transmitted infectionsHIV/syphilis co-infectionReferencesГречанская Л.В. Клинико-эпидемиологическая характеристика и лечение инфекций, передающихся половым путем, у ВИЧ-инфицированных: автореф. дис.. канд. мед. наук. Харьков, 2006. 23 с.Гречанская Л.В. Клинико-эпидемиологическая характеристика и лечение инфекций, передающихся половым путем, у ВИЧ-инфицированных: автореф. дис.. канд. мед. наук. Харьков, 2006. 23 с.Зоиров П.Т. Частная дерматология и венерология. Душанбе, 2007. 815 с.Зоиров П.Т. Частная дерматология и венерология. Душанбе, 2007. 815 с.Красносельских Т.В., Соколовский Е.В. Сифилис: старая проблема и новые вызовы // 2-й Межд. конгресс по дерматологии. СПб., 2011. С. 264Красносельских Т.В., Соколовский Е.В. Сифилис: старая проблема и новые вызовы // 2-й Межд. конгресс по дерматологии. СПб., 2011. С. 264Кубанова A.A. Анализ эпидемиологической ситуации и динамика заболеваемости инфекциями, передаваемыми половым путем, и дерматозами на территории Российской Федерации // Вестн. дерматол. и венерол. 2010. № 5. С. 4-22.Кубанова A.A. Анализ эпидемиологической ситуации и динамика заболеваемости инфекциями, передаваемыми половым путем, и дерматозами на территории Российской Федерации // Вестн. дерматол. и венерол. 2010. № 5. С. 4-22.Рафиев Х.К., Нуров Р.М., Турсунов Р.А. Эпидемические особенности развития ВИЧ-инфекции в Таджикистане // Вестник Авиценны. 2012. № 4. С. 117-121.Рафиев Х.К., Нуров Р.М., Турсунов Р.А. Эпидемические особенности развития ВИЧ-инфекции в Таджикистане // Вестник Авиценны. 2012. № 4. С. 117-121.Терзян В.А., Земцов М.А., Шаханина И.Л. Экономический ущерб, наносимый заболеванием сифилисом // Эпидемиология и инфекционные болезни. 2007. № 4. С. 20-24.Терзян В.А., Земцов М.А., Шаханина И.Л. Экономический ущерб, наносимый заболеванием сифилисом // Эпидемиология и инфекционные болезни. 2007. № 4. С. 20-24.Abdool Karim Q. The global HIV epidemic: current status and challenges // Curr. HIV/AIDS Rep. 2013. Vol. 10, No. 2. P. 111-112. DOI 10.1007/s11904-013-0160-1.Abdool Karim Q. The global HIV epidemic: current status and challenges // Curr. HIV/AIDS Rep. 2013. Vol. 10, No. 2. P. 111-112. DOI 10.1007/s11904-013-0160-1.Buchacz K., Patel P., Taylor M. [et al.] Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections // AIDS. 2004. Vol. 18. P. 2075-2079.Buchacz K., Patel P., Taylor M. [et al.] Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections // AIDS. 2004. Vol. 18. P. 2075-2079.Burchell A.N., Allen V.G., Moravan V. [et al.] Patterns of syphilis testing in a large cohort of HIV patients in Ontario, Canada, 2000-2009 // BMC Infect. Dis. 2013. Vol. 28, No. 13. P. 246.Burchell A.N., Allen V.G., Moravan V. [et al.] Patterns of syphilis testing in a large cohort of HIV patients in Ontario, Canada, 2000-2009 // BMC Infect. Dis. 2013. Vol. 28, No. 13. P. 246.Boily M.C., Baggaley R.F., Wang L. [et al] Heterosexual risk of HIV-1 infection per sexual act: systematic review and metaanalysis of observational studies // The Lancet infectious diseases. 2009. Vol. 9, No. 2. P. 118-129.Boily M.C., Baggaley R.F., Wang L. [et al] Heterosexual risk of HIV-1 infection per sexual act: systematic review and metaanalysis of observational studies // The Lancet infectious diseases. 2009. Vol. 9, No. 2. P. 118-129.Callegari F.M., Pinto-Neto L.F., Medeiros C.J. [et al.] Syphilis and HIV co-Infection in patients who attend an AIDS Outpatient Clinic in Vitoria, Brazil // AIDS Behav. 2013. Vol. 4. DOI 10.1007/ s10461-013-0533-x.Callegari F.M., Pinto-Neto L.F., Medeiros C.J. [et al.] Syphilis and HIV co-Infection in patients who attend an AIDS Outpatient Clinic in Vitoria, Brazil // AIDS Behav. 2013. Vol. 4. DOI 10.1007/ s10461-013-0533-x.Centers for Disease Control and Prevention // Sexually Transmitted Diseases Treatment Guidelines. MMWR 2006. Vol. 55, No. RR-11. 38 p.Centers for Disease Control and Prevention // Sexually Transmitted Diseases Treatment Guidelines. MMWR 2006. Vol. 55, No. RR-11. 38 p.Chow E.P., Iu K.I., Fu X. [et al.] HIV and sexually transmissible infections among money boys in China: a data synthesis and meta-analysis // PLoS One. 2012. Vol. 7, No. 11. P. e48025.Chow E.P., Iu K.I., Fu X. [et al.] HIV and sexually transmissible infections among money boys in China: a data synthesis and meta-analysis // PLoS One. 2012. Vol. 7, No. 11. P. e48025.Diez M., Diaz A. Sexually transmitted infections: epidemiology and control // Rev. Esp. Sanid. Penit. 2011. Vol. 13, No. 2. P. 58-66.Diez M., Diaz A. Sexually transmitted infections: epidemiology and control // Rev. Esp. Sanid. Penit. 2011. Vol. 13, No. 2. P. 58-66.Hayes R.J., Schulz K., Plummer F.A. The cofactor effect of genital ulcers in the perexposure risk of HIV transmission in sub-Saharan Africa // J. Tropical Medicine and Hygiene. 1995. Vol. 98. P. 1-8.Hayes R.J., Schulz K., Plummer F.A. The cofactor effect of genital ulcers in the perexposure risk of HIV transmission in sub-Saharan Africa // J. Tropical Medicine and Hygiene. 1995. Vol. 98. P. 1-8.Kalichman S.C., Pellowski J., Turner C. Prevalence of sexually transmitted coinfections in people living with HIV/AIDS: systematic review with implications for using HIV treatments for prevention // Sexually transmitted infections. 2011. Vol. 87, No. 3. С. 183-190.Kalichman S.C., Pellowski J., Turner C. Prevalence of sexually transmitted coinfections in people living with HIV/AIDS: systematic review with implications for using HIV treatments for prevention // Sexually transmitted infections. 2011. Vol. 87, No. 3. С. 183-190.Li P., Chen X., Xie P.Y. [et al.] HIV infection among new synthetic drug abusers: a pilot study in Beijing // Chin. Med. J. (Engl). 2013. Vol. 126, No. 8. P. 1517-1521.Li P., Chen X., Xie P.Y. [et al.] HIV infection among new synthetic drug abusers: a pilot study in Beijing // Chin. Med. J. (Engl). 2013. Vol. 126, No. 8. P. 1517-1521.Liu J., Huang Y., Wang J. [et al.] The increasing prevalence of serologic markers for syphilis among Chinese blood donors in 2008 through 2010 during a syphilis epidemic // Transfusion. 2012. Vol. 52, No. 8. P. 1741-1749.Liu J., Huang Y., Wang J. [et al.] The increasing prevalence of serologic markers for syphilis among Chinese blood donors in 2008 through 2010 during a syphilis epidemic // Transfusion. 2012. Vol. 52, No. 8. P. 1741-1749.Malincarne L., Angeli G., Francisci D. [et al.] Trend of syphilis among patients at the Infectious Diseases Clinic of Perugia, Italy: a six-year observational retrospective study // Infez. Med. 2013. Vol. 21, No. 1. P. 14-20.Malincarne L., Angeli G., Francisci D. [et al.] Trend of syphilis among patients at the Infectious Diseases Clinic of Perugia, Italy: a six-year observational retrospective study // Infez. Med. 2013. Vol. 21, No. 1. P. 14-20.Martinelli C.V., Tognetti L., Colao G. [et al.] Syphilis with HIV in Florence, 2003-2009: a 7-year epidemiological study // Epidemiol. Infect. 2012. Vol. 140, No. 1. P. 168-171.Martinelli C.V., Tognetti L., Colao G. [et al.] Syphilis with HIV in Florence, 2003-2009: a 7-year epidemiological study // Epidemiol. Infect. 2012. Vol. 140, No. 1. P. 168-171.Muldoon E., Mulcahy F. Syphilis resurgence in Dublin, Ireland // Int. J. STD AIDS. 2011. Vol. 22, No. 9. P. 493-497.Muldoon E., Mulcahy F. Syphilis resurgence in Dublin, Ireland // Int. J. STD AIDS. 2011. Vol. 22, No. 9. P. 493-497.Nelson K.E., Williams C.M. Infectious disease epidemiology. Jones & Bartlett Publishers, 2013. 1207 p.Nelson K.E., Williams C.M. Infectious disease epidemiology. Jones & Bartlett Publishers, 2013. 1207 p.Ouedraogo A. Impact of suppressive herpes therapy on genital HIV RNA among women taking antiretroviral therapy: a randomized controlled trial // AIDS. 2006. Vol. 20, No. 18. P. 2305-2313.Ouedraogo A. Impact of suppressive herpes therapy on genital HIV RNA among women taking antiretroviral therapy: a randomized controlled trial // AIDS. 2006. Vol. 20, No. 18. P. 2305-2313.Schuelter-Trevisol F., Custodio G., Silva A.C. [et al.] HIV, hepatitis B and C, and syphilis prevalence and coinfection among sex workers in Southern Brazil // Rev. Soc. Bras. Med. Trop. 2013. Vol. 46, No. 4. P. 493-497.Schuelter-Trevisol F., Custodio G., Silva A.C. [et al.] HIV, hepatitis B and C, and syphilis prevalence and coinfection among sex workers in Southern Brazil // Rev. Soc. Bras. Med. Trop. 2013. Vol. 46, No. 4. P. 493-497.Scythes J.B., Jones C.M. Syphilis in the AIDS era: Diagnostic dilemma and therapeutic challenge // Acta Microbiol. Immunol. Hung. 2013. Vol. 60, No. 2. P. 93-116.Scythes J.B., Jones C.M. Syphilis in the AIDS era: Diagnostic dilemma and therapeutic challenge // Acta Microbiol. Immunol. Hung. 2013. Vol. 60, No. 2. P. 93-116.Sherman K.E., Shire N.J., Rouster S.D. [et al.] Hepatitis C virus prevalence among patients infected with human immunodeficiency virus // Clin. Infect. Dis. 2005. Vol. 128. P. 313-327.Sherman K.E., Shire N.J., Rouster S.D. [et al.] Hepatitis C virus prevalence among patients infected with human immunodeficiency virus // Clin. Infect. Dis. 2005. Vol. 128. P. 313-327.Renton A., Gzirishvilli D., Gotsadze G., Godinho J. Epidemics of HIV sexually transmitted infections in Central Asia // International Journal of Drug Policy. 2006. Vol. 17. P. 494-503.Renton A., Gzirishvilli D., Gotsadze G., Godinho J. Epidemics of HIV sexually transmitted infections in Central Asia // International Journal of Drug Policy. 2006. Vol. 17. P. 494-503.Riedner G., Dehne K., Gromyko A. Recent declines in reported syphilis rates in Eastern Europe and Central Asia: are the epidemics over // British Medical Journal. 2000. Vol. 76. P. 363-365.Riedner G., Dehne K., Gromyko A. Recent declines in reported syphilis rates in Eastern Europe and Central Asia: are the epidemics over // British Medical Journal. 2000. Vol. 76. P. 363-365.Tucker J.D., Myron S. China›s syphilis epidemic: epidemiology, proximate determinants of spread, and control responses // Curr. Opin. Infect. Dis. 2011. Vol. 24, No. 1. P. 50-55.Tucker J.D., Myron S. China›s syphilis epidemic: epidemiology, proximate determinants of spread, and control responses // Curr. Opin. Infect. Dis. 2011. Vol. 24, No. 1. P. 50-55.Walker G.J., Walker D.G. Congenital syphilis: a continuing but neglected problem // Seminars in Fetal and Neonatal Medicine. 2007. Vol. 12, No. 3. P. 198-206.Walker G.J., Walker D.G. Congenital syphilis: a continuing but neglected problem // Seminars in Fetal and Neonatal Medicine. 2007. Vol. 12, No. 3. P. 198-206.Weintrob A.C., Gu W., Qin J. [et al.] Syphilis coinfection does not affect HIV disease progression // Int. J. STD AIDS. 2010. Vol. 21, No. 1. P. 57-59.Weintrob A.C., Gu W., Qin J. [et al.] Syphilis coinfection does not affect HIV disease progression // Int. J. STD AIDS. 2010. Vol. 21, No. 1. P. 57-59.Wibmer A., Stift A., Wrba F. [et al.] Syphilis: the great mimicker // Int. J. Dermatol. 2012. DOI 10.1111/j.1365-4632.2012.05760.x.Wibmer A., Stift A., Wrba F. [et al.] Syphilis: the great mimicker // Int. J. Dermatol. 2012. DOI 10.1111/j.1365-4632.2012.05760.x.WHO: Global incidence and prevalence of selected curable sexually transmitted infections // World Health Organization, Dept. of Reproductive Health and Research. 2008. 20 с.WHO: Global incidence and prevalence of selected curable sexually transmitted infections // World Health Organization, Dept. of Reproductive Health and Research. 2008. 20 с.Wu J., Huang J., Xu D. [et al.] Infection status and risk factors of HIV, HBV, HCV, and syphilis among drug users in Guangdong, China - a cross-sectional study // BMC Public Health. 2010. Vol. 1, No. 10. P. 657.Wu J., Huang J., Xu D. [et al.] Infection status and risk factors of HIV, HBV, HCV, and syphilis among drug users in Guangdong, China - a cross-sectional study // BMC Public Health. 2010. Vol. 1, No. 10. P. 657.Zhang X., Chow E.P., Wilson D.P. [et al.] Prevalence of HIV and syphilis infections among long-distance truck drivers in China: a data synthesis and meta-analysis // Int. J. Infect. Dis. 2013. Vol. 17, No. 1. P. e2-7.Zhang X., Chow E.P., Wilson D.P. [et al.] Prevalence of HIV and syphilis infections among long-distance truck drivers in China: a data synthesis and meta-analysis // Int. J. Infect. Dis. 2013. Vol. 17, No. 1. P. e2-7.

The authors declare that there are no conflicts of interest present.