Background. The purpose of this research is to find out the efficiency of pharmaceutical treatment of progressive glaucoma associated optic neuropathy with using retrobulbar catheterization Methods. Was observed 54 patients from 52 to 84 years old (59 eyes) with nonstabilized primary open-angle glaucoma. Treatment was began with insertion under local anesthesia of retrobulbar catheter, with help of which for 10 days long was injected retinalamin. At the same time under the skin of temple was injected histochrom, was provided intravenous infusions mexidol and choline alfosceras, intramuscular was injected milgamma. After the end of course of therapy catheter was extracted and was appointed per os systemics the same groups for 2 months. Results. In all cases of examinations tolerant intraocular pressure staying on a mean value. Visual field expanded, generally because of reduction or total elimination of relative scotomas. In observation with developed stage of fast progressive and slow progressive glaucoma associated optic neuropathy decreasing of index of progression was registered and after 6 and 12 months. With advanced stage of glaucoma associated optic neuropathy decreasing of index of progression was verifiable only with fast progressive disease state. Conclusions. Efficiency of retrobulbar catheterization was demonstrated by the results of functional and morphometric research of optic nerve with course of neuroprotective treatment under conditions of normalized intraocular pressure with intention to slow down development of glaucoma associated optic neuropathy.