Background. One of the possible ways of microbiocenosis correction at parodont inflammatory diseases is the treatment with the probiotic microorganisms. Methods. To 35 of 68 patients of 20-60 years old with chronic generalized paradontitis of mild and moderate severity level the treatment was contributed by the washing of the parodontal pockets by the probiotic “Euflorin L” (the main group). To the remained 33 patients (control group) standard washing of the oral cavity with the parodontal pockets irrigation by only 0.05 % chlorine hexidine solution was done. The level of the oral cavity hygiene was estimated by the standard stomatologic indexes. A state of local immunity was studied by the reaction of adsorption of microorganisms, phagocyte activity of leukocytes, the test with nitro blue tetrasolium, the index of the neutrophil activation and by the level of IGA in saliva. The exam was done before the treatment, in a week, 3 and 6 months after the treatment. Results. In a week after the treatment at all patients the state of oral cavity has essentially improved, but immunologic indicators have improved only in the main group. In 3 months in both groups the positive dynamics of clinical symptoms remained, but in the main group the increase of phagocyte index and level of secretory antibodies as well as the increase of the adsorption activity of the epitheliocytes is shown. In 6 months at patients who underwent parodontal pockets washing by euflorin L, the phagocyte activity of leukocytes has increased as well as the adsorption activity of the epithelial cells, but the level of the secretory antibodies in saliva remained almost the same. Conclusions. Probiotic medications with the alive not-lyophilized strains of the lactobacteria not only positively influence the clinical state of the parodont tissues reducing the inflammation expressiveness but also improve the level of the indicators of local immunity.