pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-664Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESАнализ показателей матриксных металлопротеиназ и их ингибиторов до и после дентальной имплантацииThe analysis of indicators of matrix metal proteinases and their inhibitors before and after the dental implantationЮгайЮ. В.YugaiYu. V.yury.yugay@yandex.ruГолицынаА. А.GolitsynaA. A.noemail@neicon.ruТолмачевВ. Е.TolmachyovV. E.noemail@neicon.ruМаркеловаЕ. В.MarkelovaE. V.noemail@neicon.ruТихоокеанский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation201428092014036567Copyright © Югай Ю.В., Голицына А.А., Толмачев В.Е., Маркелова Е.В., 20142014Югай Ю.В., Голицына А.А., Толмачев В.Е., Маркелова Е.В.Yugai Y.V., Golitsyna A.A., Tolmachyov V.E., Markelova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/664

Проведен анализ системного и локального содержания матриксных металлопротеиназ (MMPs) 8 и 9 и их тканевого ингибитора (TIMP1) у пациентов до и после операции дентальной имплантации. Выявлено достоверное увеличение MMPs и TIMP1 при наличии ранних послеоперационных осложнений. Изучение качественных и количественных характеристик ММРs и их ингибиторов представляет собой перспективное направление фундаментальных исследований, которое позволит разработать новые подходы к диагностике и лечению осложнений при дентальной имплантации.

Background. An important aspect of occurrence of early complications of dental implantation and inflammation in the implantation area is integrity of a connecting tissue surrounding it while its injury influences the balance of the tissue metalloproteinase-1 inhibitor (TIMP1) and matrix metalloproteinase (MMPs) 8 and 9. Methods. 80 patients at the age of 30-60 years old who underwent dental implantation were examined. In 70 cases the postoperative period had no complications (1st group); at 10 cases there were early complications - an edema and hyperemia of the soft tissues (2nd group). In blood and the mixed oral liquid the levels of MMP-8, MMP-9 and TIMP1 were determined. For the control authors investigated the blood and the oral liquid of 20 practically healthy people. Results. Statistically significant increase of the systemic level of ММР-8 is revealed, MMP-9 and TIMP1 has been considerably raised at patients of 2nd group. At patients with not complicated postoperative period local and systemic increase of concentration of MMP-9 and local increase of concentration of TIMP1 is found. Conclusions. Studying of qualitative and quantitative characteristics of ММРs and their inhibitors is a perspective direction of basic researches which will allow developing the new approaches to diagnostics and treatment of complications at dental implantation.

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The authors declare that there are no conflicts of interest present.