pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-701Research ArticleМЕТОДИКАMETHODSРАЗРАБОТКА ТЕХНОЛОГИИ БЫСТРОРАСТВОРИМОЙ ФОРМЫ АЛЬГИНАТА НАТРИЯDEVELOPMENT OF TECHNOLOGY FOR QUICK-DISSOLVING FORM OF SODIUM ALGINATEКовалевВ. В.KovalevV. V.noemail@neicon.ruХотимченкоР. Ю.KhotimchenkoR. Yu.noemail@neicon.ruПодкорытоваЕ. А.PodkorytovaE. A.noemail@neicon.ruХожаенкоЕ. В.KhozhaenkoE. V.noemail@neicon.ruИнститут биологии моря им. А.В. Жирмунского ДВО РАН; Дальневосточного федерального университетаРоссияInstitute of Marine Biology named after A.V. Zhirmunskiy FEB RAS; Far Eastern Federal UniversityRussian FederationИнститут биологии моря им. А.В. Жирмунского ДВО РАНРоссияInstitute of Marine Biology named after A.V. Zhirmunskiy FEB RASRussian Federation201428062014028892Copyright © Ковалев В.В., Хотимченко Р.Ю., Подкорытова Е.А., Хожаенко Е.В., 20142014Ковалев В.В., Хотимченко Р.Ю., Подкорытова Е.А., Хожаенко Е.В.Kovalev V.V., Khotimchenko R.Y., Podkorytova E.A., Khozhaenko E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/701

Исследовалось влияние кальция на растворимость альгината. Построена изотерма сорбции ионов кальция альгинатом натрия в среде 50 % этанола и получены образцы альгината, содержащие от 0,2 до 6,82 % кальция. Исследованы свойства гидрогелей полученных образцов альгината. Установлено, что при содержании кальция в альгинате менее 4,44 % начинается частичное растворение альгинатного геля, а при содержании кальция менее 0,8 % происходит его полное растворение. Проведена оценка скорости растворения различных образцов альгината. Образцы, содержащие 0,2-0,8 % кальция демонстрировали в 6,2-13,4 раза более высокую скорость растворения, чем исходный альгинат натрия. Дана оценка механизма влияния малых количеств кальция на растворимость альгината.

Brown algae polysaccharides - are the alginates widely used in food and pharmaceutical industries as health promoting medicines in case of poisoning with heavy metals salts and radionuclides. A significant shortcoming of the alginates is their poor solubility. The purpose of research is development of a method enhancing the sodium alginate solubility based on a transferring the part of uronic acids residues in the alginate molecule to the calcium salts form. Methods. The article covers the influence of calcium content on the alginate solubility. The researchers formed sorption isotherm of calcium ions by sodium alginate in the environment of 50 % ethanol and obtained the alginate samples containing from 0.2 to 6.82 % of calcium. Also they studied the hydrogels properties of the obtained samples of calcium alginate. Results. It was found that in the case of calcium content in the alginate less than 4.44 % a partial dissolution of the alginate gel starts, while calcium content less than 0.8 % promotes a complete dissolution. There have been also an estimation of dissolution rate for various alginate samples. Calcium alginate samples containing 0.2-0.8 % of calcium showed a higher rate of dissolution by 6.2-13.4 times than the original sodium alginate. Conclusions. Technology for producing incomplete calcium salts of alginates may be a new and very efficient approach to the problem of their solubility and, therefore, improvement of consumer properties.

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The authors declare that there are no conflicts of interest present.