pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2016.4.22-25pmj-81Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESНекоторые иммунологические механизмы невынашивания беременности и бесплодия при поллинозе и возможные пути их коррекцииImmune mechanisms of miscarriage and infertility at pollinosis and possible ways of their correctionЦывкинаГ. И.TsyvkinaG. I.galatsyvkina@mail.ruГригорьеваН. В.GrigorevaN. V.noemail@neicon.ruЛуценкоГ. А.LutsenkoG. A.noemail@neicon.ruПетроваО. В.PetrovaO. V.noemail@neicon.ruКраевой клинический центр современных видов медицинской помощиРоссияRegional Clinical Center of Modern Medical CareRussian Federation2016281220166142225Copyright © Цывкина Г.И., Григорьева Н.В., Луценко Г.А., Петрова О.В., 20162016Цывкина Г.И., Григорьева Н.В., Луценко Г.А., Петрова О.В.Tsyvkina G.I., Grigoreva N.V., Lutsenko G.A., Petrova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/81

Обследованы 22 женщины с поллинозом, имевшие в анамнезе эпизоды невынашивания беременности, и 31 женщина с поллинозом, но без отягощенного акушерского анамнеза. Изменения иммунологических параметров у пациенток с поллинозом имели схожую клиническую картину. Однако в группе с привычным невынашиванием беременности отмечалась высокая активность NK-клеток с цитотоксическим фенотипом. У женщин без отягощенного акушерского анамнеза NK-клетки определялись в пределах нормальных показателей и при беременности меняли свой фенотип на иммуносупрессивный.

Immune mechanisms involved in the pathogenesis of recurrent miscarriage and infertility. Despite the fact that fetal cells carry antigens of both mother and father, there is 'an immunological paradox' of pregnancy associated with the occurrence of immunological tolerance. Methods. The object of study - 22 women with pollinosis who had episodes of miscarriage in the medical history and 31 women with pollinosis, but without a burdened obstetric history (control group - 20 women without aggravated allergic and obstetric history). Results. Changes in immunological parameters in patients with pollinosis had a similar clinical picture. However, in the group with recurrent miscarriage noted high activity of NK-cells with a cytotoxic phenotype. In women without the burdened obstetric history NK-cells were defined within the normal range during pregnancy and changed their phenotype to immunosuppressive one. Conclusions. A preconception period program in women having had episodes of miscarriage in their medical history should cover the pollinosis screening, and in women with detected pollinosis should detect the NK-cells levels and cytoxic T lymphocytes assessing their functional activity.

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The authors declare that there are no conflicts of interest present.