pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-900Research ArticleОБЗОРЫREVIEWSСовременные представления о патогенезе болиPresent-day ideas on pathogenesis of painБалашоваТ. В.BalashovaT. V.balmik@rambler.ruАндрееваН. А.AndreevaN. A.noemail@neicon.ruМнацаканянЛ. А.MnatsakyanL. A.noemail@neicon.ruКотельниковаА. Г.KotelnikovaA. G.noemail@neicon.ruДолгуновА. М.DolgunovA. M.noemail@neicon.ruВладивостокский государственный медицинский университетРоссияVladivostok State Medical UniversityRussian Federation201228092012031316Copyright © Балашова Т.В., Андреева Н.А., Мнацаканян Л.А., Котельникова А.Г., Долгунов А.М., 20122012Балашова Т.В., Андреева Н.А., Мнацаканян Л.А., Котельникова А.Г., Долгунов А.М.Balashova T.V., Andreeva N.A., Mnatsakyan L.A., Kotelnikova A.G., Dolgunov A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/900

Обзор литературы, посвященный современным патофизиологическим и нейрохимическим аспектам формирования боли. Рассмотрены вопросы участия глутаматных рецепторов, оксида азота, медиаторов воспаления, коллатерального спроутинга, феномена переключения фенотипа и других механизмов в развитии боли. Изложены современные представления о влиянии генома на развитие болевого синдрома и перспективы дальнейших исследований в этом направлении.

The paper provides an overview of the literature about the current pathophysiological and neurochemical aspects of pain generation and considers the matters relative to the role of glutamate receptors, nitrogen oxide, inflammation mediators, collateral sprouting, phenotype switchover phenomenon, and other mechanisms in the pain generation. The authors set out the up-to-date ideas about the role of genome in generating the pain syndrome, and prospects for the further researches.

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The authors declare that there are no conflicts of interest present.