pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-911Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESДефероксамин в профилактике реперфузионных повреждений эндотелия при экспериментальной ишемии/реперфузииDeferoxamine in the prevention of endothelial reperfusion injuries in case of experimental ischemia/reperfusionОрловЮ. П.OrlovYu. P.orlov-up@mail.ruЛукачВ. Н.LukachV. N.noemail@neicon.ruДолгихВ. Т.DolgikhV. T.noemail@neicon.ruСоболеваЕ. Л.SobolevaE. L.noemail@neicon.ruИвановаА. М.IvanovaA. M.noemail@neicon.ruКожевниковаЕ. Ф.KozhevnikovaE. F.noemail@neicon.ruОмская государственная медицинская академияРоссияOmsk State Medical AcademyRussian FederationИркутская областная клиническая больницаРоссияIrkutsk Oblast Clinical HospitalRussian Federation201228092012035457Copyright © Орлов Ю.П., Лукач В.Н., Долгих В.Т., Соболева Е.Л., Иванова А.М., Кожевникова Е.Ф., 20122012Орлов Ю.П., Лукач В.Н., Долгих В.Т., Соболева Е.Л., Иванова А.М., Кожевникова Е.Ф.Orlov Y.P., Lukach V.N., Dolgikh V.T., Soboleva E.L., Ivanova A.M., Kozhevnikova E.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/911

Для анализа патогенетической значимости нарушенного обмена железа в развитии эндотелиальной дисфункции в период реперфузии в опыте на 40 крысах-самцах линии «Вистар» моделировалась 15-минутная ишемия и 15-минутная реперфузия кишечника. Исследовали показатели центральной гемодинамики, вязкость крови, содержание в сыворотке крови трансферрина, ферритина, сывороточного железа и фактора Виллебранда. Выявлено, что в период реперфузии в сыворотке крови уменьшается концентрация трансферрина, увеличивается концентрация ферритина, фактора Виллебранда и регистрируются нарушения реологических свойств крови со снижением сердечного индекса и общего периферического сосудистого сопротивления. Предварительное введение дефероксамина приводило к восстановлению концентрации трансферрина, снижению уровня ферритина, нормализации реологии крови и показателей гемодинамики, и отмечалось снижение степени деструкции эндотелия, что связано с уменьшением концентрации в сыворотке крови Fe2+. Заключение: предварительным введением дефероксамина можно эффективно предупреждать повреждения эндотелия во время реперфузии при критических состояниях.

15-minute ischemia and 15-minute intestinal reperfusion have been simulated to analyse the pathogenetic importance of the impaired iron exchange in forming endothelial dysfunction during the reperfusion in the experiment on 40 ‘Vistar’ male rats. The authors studied the central hemodynamics indices, blood viscosity, content of transferrin, ferritin, serum iron and von Willebrand factor, and revealed that during the reperfusion the transferrin content decreased, the ferritin content and the von Willebrand factor increased, and there were disturbances in the rheological properties of blood with the tendency towards the decrease in the cardiac index and total peripheral vascular resistance. The preliminary infusion of deferoxamine allowed recovery of the transferrin content, decrease of the ferritin level, normalisation of the blood rheology and hemodynamics indices. This appeared to result in the reduction of the endothelial destruction due to reducing content of Fe2+ in blood serum. As a conclusion, the preliminary infusion of deferoxamine allows efficiently prevent the endothelium injuries during the reperfusion under critical conditions.

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The authors declare that there are no conflicts of interest present.