pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-912Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESСвязь системной эндотелиальной дисфункции с развитием легочной гипертензии у детей с хронической бронхолегочной патологиейRole of systemic endothelial dysfunction in the progress of lung hypertension in children with chronic bronchopulmonary pathologyАгапитовЛ. И.AgapitovL. I.lagapitov@rambler.ruБелозеровЮ. М.BelozerovYu. M.noemail@neicon.ruМизерницкийЮ. Л.MizernitskiyYu. L.noemail@neicon.ruМосковский НИИ педиатрии и детской хирургииРоссияMoscow Research Institute of Paediatrics and Children’s SurgeryRussian Federation201228092012035862Copyright © Агапитов Л.И., Белозеров Ю.М., Мизерницкий Ю.Л., 20122012Агапитов Л.И., Белозеров Ю.М., Мизерницкий Ю.Л.Agapitov L.I., Belozerov Y.M., Mizernitskiy Y.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/912

Обследовано 180 здоровых и 359 детей, страдавших тяжелой бронхиальной астмой, заболеваниями с формированием бронхоэктазов и гиперчувствительным пневмонитом. Изучалась сосудодвигательная функция эндотелия на основе измерения реакции плечевой артерии на реактивную гиперемию. Максимальная эндотелийзависимая вазодилатация у больных с легочной гипертензией была достоверно меньше, чем у здоровых. Тотальная эндотелийзависимая вазодилатация и коэффициент чувствительности эндотелия к напряжению сдвига у больных с легочной гипертензией были достоверно меньше, чем у таких же пациентов с нормальным давлением в легочной артерии и здоровых детей. Установлена отрицательная корреляция показателей эндотелийзависимой вазодилатации со средним давлением в легочной артерии. Показано, что функциональное состояние эндотелия играет важную роль в патогенезе легочной гипертензии, независимо от характера заболевания. Факторами риска легочной гипертензии у детей с хронической бронхолегочной патологией являются значение максимальной эндотелийзависимой вазодилатации менее 10 %, показатель тотальной эндотелийзависимой вазодилатации менее 850 %-с, значение коэффициента чувствительности эндотелия к напряжению сдвига менее 25.

The authors have examined 180 healthy children and 359 children with severe bronchial asthma associated with bronchiectasis and hypersensitive pneumonitis in an effort to study the endothelial vasomotor function by measuring brachial artery response on the reactive hyperaemia. The maximum endothelium-dependent vasodilatation in patients with pulmonary hypertension was reliably lesser than that of the healthy people. The total endothelium-dependent vasodilatation and the coefficient of endothelial sensitivity to shift tension in patients with the lung hypertension were reliably lesser than those of the patients with normal pressure in the lung artery and healthy children. The authors found out the negative correlation of the endothelium-dependent vasodilatation with average pressure in the lung artery and revealed that the functional state of the endothelium has had the important role in the pathogenesis of the lung hypertension, irrespective of the type of the disease. As reported, the risk factors for the lung hypertension in children with the chronic bronchopulmonary pathology include the value of the maximum endothelium-dependent vasodilatation of less than 10%, the index of the total endothelium-dependent vasodilatation of less than 850 %-с, the value of the coefficient of the endothelial sensitivity to the shift tension of less than 25.

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The authors declare that there are no conflicts of interest present.