References

pmj

Тихоокеанский медицинский журнал

Pacific Medical Journal

1609-1175

TGMU

pmj-931

Research Article

ОБЗОРЫ

REVIEWS

Значение сероводорода в регуляции функций органов

ROLE OF HYDROGEN SULPHIDE IN REGULATORY FUNCTIONS

Вараксин

А. А.

Varaksin

A. A.

inmarbio@mail.primorye.ru

Пущина

Е. В.

Puschina

E. V.

noemail@neicon.ru

Институт биологии моря им. А.В.Жирмунского ДВО РАНРоссияA.V. Zhirmunsky Institute of Marine BiologyRussian Federation

2012

28062012

022736

2012

Вараксин А.А., Пущина Е.В.

Varaksin A.A., Puschina E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.tmj-vgmu.ru/jour/article/view/931

В обзоре рассматриваются новые данные литературы и результаты собственных исследований по физиологии и патологии газотрансмиттера сероводорода. Сероводород синтезируется из цистеина с помощью пиридоксаль-5’-фосфат-зависимых ферментов цистатионин-р-синтазы или цистатионин-у-лиазы. Он стимулирует АТФ-зависимые калиевые каналы в гладкомышечных клетках сосудов, нейронах, кардиомиоцитах и β-клетках поджелудочной железы, участвуя в регуляции сосудистого тонуса, сокращении кардиомиоцитов, нейротрансмиссии и секреции инсулина. Рассматривается влияние сероводородпродуцирующих систем в патогенезе артериальной и легочной гипертензии, болезни Альцгеймера, циррозе печени.

Summary - The paper provides new published data and results of authors’ studies on physiology and pathology of hydrogen sulphide gas transmitter. The hydrogen sulphide is synthesised from cysteine by pyridoxal-5’-phosphate-dependent enzymes of cystathionine-ß-synthase or cystathionine-Y-lyase. It stimulates the ATP-dependent potassium channels in the vascular smooth muscle cells, neurons, cardiomyocytes, and ß-cells of pancreatic gland, thus being involved in regulation of vasomotor tone, reduction of cardiomyocytes, neurotransmission, and insulin secretion. The authors describe effects of hydrogen sulphide-inducing systems on the pathogenesis of arterial and lung hypertension, Alzheimer disease, and liver cirrhosis.

газотрансмиттерысероводородвисцеральные системы

gas transmittershydrogen sulphidevisceral systems

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The authors declare that there are no conflicts of interest present.