pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-934Research ArticleОБЗОРЫREVIEWSБиосовместимые матриксные имплантаты на основе природных и синтетических полимеров как перспективные средства для терапии дегенеративных и посттравматических заболеваний центральной нервной системыBIOCOMPATIBLE MATRIX IMPLANTS FROM NATURAL AND SYNTHETIC POLYMERS AS PROMISING PRODUCTS INTENDED FOR TREATMENT OF DEGENERATIVE AND POST-INJURY DISEASES OF CENTRAL NERVOUS SYSTEMХотимченкоЮ. С.KhotimchenkoYu. S.noemail@neicon.ruЩеблыкинаА. В.ScheblyikinaA. V.noemail@neicon.ruКумейкоВ. В.KumeikoV. V.vkumeiko@yandex.ruИнститут биологии моря им. А.В. Жирмунского Дальневосточного отделения РАН; Дальневосточный федеральный университетРоссияA.V. Zhirmunsky Institute of Marine Biology; Far Eastern Federal UniversityRussian FederationИнститут биологии моря им. А.В. Жирмунского Дальневосточного отделения РАНРоссияA.V. Zhirmunsky Institute of Marine BiologyRussian Federation201228062012025460Copyright © Хотимченко Ю.С., Щеблыкина А.В., Кумейко В.В., 20122012Хотимченко Ю.С., Щеблыкина А.В., Кумейко В.В.Khotimchenko Y.S., Scheblyikina A.V., Kumeiko V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/934

Обзор современных исследований и разработок в области создания биосовместимых имплантируемых материалов для терапии дегенеративных и посттравматических патологий центральной нервной системы. Проведен критический анализ материалов и их компонентов на основе природных и синтетических полимеров, применение которых в качестве матриксных имплантатов может способствовать восстановлению целостности поврежденного мозга, осуществлению заместительных и трофических функций, индукции репаративных процессов за счет внутренних и имплантируемых клеточных источников. Современное состояние биомедицинского материаловедения и тканевой инженерии для нужд нейротрансплантологии охарактеризовано в форме анализа способности материалов имитировать структуры и функции естественного внеклеточного матрикса, индуцировать нейрогенез и восстановление проводниковых функций нервной системы, а также способности материалов подвергаться контролируемой биодеградации с последующим замещением тканевыми структурами организма.

The authors provide an overview of modern studies and developments in the field of biocompatible implantable materials designed for treating degenerative and post-injury pathologies of central nervous system. As reported, the critical analysis of materials and their components derived from natural and synthetic polymers allows concluding that their application as matrix implants can make it possible to recover the integrity of injured brain, adjust supportive and trophic functions, and induce reparative processes due to inner and implantable cell sources. The up-to-date state of biomedical material sciences and tissue engineering for the needs of neurotransplantology is characterised as analysis of capability of materials to imitate the structure and functions of natural extracellular matrix, inducing neurogenesis and recovering conductive functions of the nervous system, and capabilities of materials to be exposed to controlled biodegradation with subsequent substitution with tissue structures.

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The authors declare that there are no conflicts of interest present.