References

pmj

Тихоокеанский медицинский журнал

Pacific Medical Journal

1609-1175

TGMU

pmj-935

Research Article

ОБЗОРЫ

REVIEWS

Стволовые клетки нейронального происхождения в мозге млекопитающих

STEM CELLS OF NEURONAL ORIGIN IN MAMMAL’S BRAIN

Охотин

В. Е.

Okhotin

V. E.

noemail@neicon.ru

Ревищин

А. В.

Revischin

A. V.

revishchin@mail.ru

Павлова

Г. В.

Pavlova

G. V.

noemail@neicon.ru

Институт биологии гена РАНРоссияInstitute of Gene Biology, RASRussian Federation

Институт проблем экологии и эволюции им. А.Н. Северцова РАНРоссияA.N. Severtsov Institute of Ecology and EvolutionRussian Federation

2012

28062012

026065

2012

Охотин В.Е., Ревищин А.В., Павлова Г.В.

Okhotin V.E., Revischin A.V., Pavlova G.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.tmj-vgmu.ru/jour/article/view/935

В последние 15 лет получены новые знания о стволовых клетках, позволяющие по-новому понять функционирование нервной ткани в норме и патологии. Показано, что пролиферирующие стволовые клетки в дефинитивном мозге при определенных условиях могут участвовать в репаративной регенерации, замещая погибшие элементы. Установлены геномные механизмы управления пролиферацией и дифференцировкой стволовых клеток. Показано их участие в генезе злокачественных опухолей и тропизм этих клеток к опухолям. Данные факты открывают новые направления в исследовании функционирования и развития мозга. Нейтральные стволовые клетки могут быть использованы для создания новых технологий, лечения нейродегенеративных и онкологических заболеваний мозга.

New knowledge about stem cells that make it possible to in a new light interpret the functioning of nervous tissue in health and disease has been obtained during the last fifteen years. As reported, the proliferating stem cells in a definitive brain under certain conditions can be involved in reparative regeneration by substituting dead elements. The authors identify genome mechanisms of regulating proliferation and differentiation of stem cells and point out their role in producing malignant tumours and tropism of these cells to the tumours. These data open new opportunities for studying brain functioning and development. The neutral stem cells can be used to develop new technologies, treat neurogenerative and oncological diseases of brain.

стволовые клеткинейронымозгдифференцировка и трансплантация

stem cellsneuronsbraindifferentiation and transplantation

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The authors declare that there are no conflicts of interest present.