pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-940Research ArticleОБЗОРЫREVIEWSВозрастные изменения нервного аппарата сердца и содержания в нем оксида азота в норме и при патологииAge-related changes of nervous apparatus of heart and its nitric oxide content in health and diseaseШвалевВ. Н.ShvalevV. N.noemail@neicon.ruИнститут клинической кардиологии им. А.Л. МясниковаРоссияA.L. Myasnikov Institute of Clinical CardiologyRussian Federation201228062012029499Copyright © Швалев В.Н., 20122012Швалев В.Н.Shvalev V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/940

В обзоре рассмотрены вопросы пре- и постнатального онтогенеза иннервации сердечно-сосудистой системы и содержания в ганглиях сердца нитроксидсинтазы в норме и патологии. Работа основана на анализе 12 серий зародышей человека, исследовании сердечно-сосудистой системы у 23 плодов, а также материалах 124 ранних вскрытий людей разного возраста в норме, при внезапной сердечной смерти и ряде кардиологических заболеваний, изученных нейрогистологическими, гистохимическими и ультраструктурными методами, а также иммуногистохимическими способами, на содержание нитроксидсинтазы.

The paper considers issues of pre- and post-natal ontogenesis of cardiovascular system innervation and nitroxidesynthase contents in heart ganglions in health and disease. The paper bases upon analysis of 12 series of human embryos, study of cardiovascular system in 23 foetuses and materials of 124 early autopsies of people of various age in health, in case of sudden cardiac death and a number of cardiological diseases studied with neurohistological, histochemical and ultrastructural methods, and immunohistochemical methods for the nitric oxide synthase contents. The author presents results of parallel time-frequency spectral analysis of heart rhythm variability in health and ischemic disease in 43 patients of various ages.

вегетативная нервная системаинволюция адренергических сплетенийвариабельность сердечного ритмаоксид азотаvegetative nervous systemadrenergic plexus involutionheart rhythm variabilitynitric oxideReferencesAlthoff X. The sudden death syndrome in children. M.: Nauka, 1983. 144 p.Althoff X. The sudden death syndrome in children. M.: Nauka, 1983. 144 p.Vanin A.F. The development of the doctrine about innervtsii heart ontogeny in health and disease, Biohimija. 1998. No. 7. P. 924-938.Vanin A.F. The development of the doctrine about innervtsii heart ontogeny in health and disease, Biohimija. 1998. No. 7. P. 924-938.Govyrin V.A. The trophic function of the sympathetic nerves and skeletal muscles. L.: Nauka, 1967. 132 p.Govyrin V.A. The trophic function of the sympathetic nerves and skeletal muscles. L.: Nauka, 1967. 132 p.Zorin A.V, Noeva E.A., Haspekova N.B. et al. The violations of autonomic regulation in myocardial ischemia, Ter. arhiv. 1999. No. 9. P. 57-61.Zorin A.V, Noeva E.A., Haspekova N.B. et al. The violations of autonomic regulation in myocardial ischemia, Ter. arhiv. 1999. No. 9. P. 57-61.Kalinichenko S.G., Motavkin P.A. The bark of the cerebellum. M.: Nauka, 2005. 319 p.Kalinichenko S.G., Motavkin P.A. The bark of the cerebellum. M.: Nauka, 2005. 319 p.Kargina-Terenteva R.A. The innervation of the adrenal glands in some types of cardiovascular disease, Kardiologija. 2006. No. 7. P. 85-88.Kargina-Terenteva R.A. The innervation of the adrenal glands in some types of cardiovascular disease, Kardiologija. 2006. No. 7. P. 85-88.Kolosov N.G. The vegetative node. L.: Nauka, 1972. 33 p.Kolosov N.G. The vegetative node. L.: Nauka, 1972. 33 p.Korkoshko O.V The cardiovascular system and age. M.: Medicina, 1983. 176 p.Korkoshko O.V The cardiovascular system and age. M.: Medicina, 1983. 176 p.Korochkin L.I., Mihajlov A.T. Introduction to neurogenetics. M.: Nauka, 2000. 274 p.Korochkin L.I., Mihajlov A.T. Introduction to neurogenetics. M.: Nauka, 2000. 274 p.Lepehina L.M. Adaptive-trophic influence of the cervical sympathetic ganglion. L.: Nauka, 1984. 98 p.Lepehina L.M. Adaptive-trophic influence of the cervical sympathetic ganglion. L.: Nauka, 1984. 98 p.Motavkin P.A. Modern views of the cerebral blood flow regulation mechanisms, Morfologija. 1992. No. 7-8. P 7-34.Motavkin P.A. Modern views of the cerebral blood flow regulation mechanisms, Morfologija. 1992. No. 7-8. P 7-34.Motavkin P.A., Zuga M.V. Nitric oxide and its role in the regulation of lung function, Morfologija. 1998. No. 5. P. 99-111.Motavkin P.A., Zuga M.V. Nitric oxide and its role in the regulation of lung function, Morfologija. 1998. No. 5. P. 99-111.Motavkin P.A. The introduction to neurobiology. Vladivostok: Medicina DV, 2003. 250 p.Motavkin P.A. The introduction to neurobiology. Vladivostok: Medicina DV, 2003. 250 p.Motavkin P.A., Tiwenko O.V, Eliseeva E.V The significance of nitric oxide in the development of cardiac hypertrophy under experimental renal hypertension, Citologija. 2002. No. 3. P. 263-269.Motavkin P.A., Tiwenko O.V, Eliseeva E.V The significance of nitric oxide in the development of cardiac hypertrophy under experimental renal hypertension, Citologija. 2002. No. 3. P. 263-269.Ohotin V.E., Shuklin A.V. The value of the neuronal, endothelial and inducible NO-synthase isoforms in cardiac muscle histophysiology, Morfologija. 2006. No. 1. P 7-18.Ohotin V.E., Shuklin A.V. The value of the neuronal, endothelial and inducible NO-synthase isoforms in cardiac muscle histophysiology, Morfologija. 2006. No. 1. P 7-18.Reutov V.P., Sorokina E.G., Ohotin V.E., Kosicin N.S. The cyclic conversion of nitric oxide in the body of mammals. M.: Nauka, 1997. 156 p.Reutov V.P., Sorokina E.G., Ohotin V.E., Kosicin N.S. The cyclic conversion of nitric oxide in the body of mammals. M.: Nauka, 1997. 156 p.Trenin C.O., Kolesnikov L.L. The reinnervation morphological and functional aspects of transplanted heart. M., 1995. 232 p.Trenin C.O., Kolesnikov L.L. The reinnervation morphological and functional aspects of transplanted heart. M., 1995. 232 p.Udelnov M.G. The physiology of the heart. M.: MGU, 1975. 304 p.Udelnov M.G. The physiology of the heart. M.: MGU, 1975. 304 p.Chazov E.I. The modern problems of Cardiology, Trudy VKNC AMN SSSR. T. 1. 1977. P 3-119.Chazov E.I. The modern problems of Cardiology, Trudy VKNC AMN SSSR. T. 1. 1977. P 3-119.Chazov E.I. Dysregulation and hyperactivity as factors of disease, Kardiologicheskij vestnik. 2006. T. I (III), No. 1. P 5-9.Chazov E.I. Dysregulation and hyperactivity as factors of disease, Kardiologicheskij vestnik. 2006. T. I (III), No. 1. P 5-9.Shvalev V.N. The age-related changes in the regulatory mechanisms of the cardiovascular system and the value nitroksidsintazy in health and disease, Kardiologija. 2007. No. 5. P 67-72.Shvalev V.N. The age-related changes in the regulatory mechanisms of the cardiovascular system and the value nitroksidsintazy in health and disease, Kardiologija. 2007. No. 5. P 67-72.Shvalev V.N., Sosunov A.A., Guski G. The morphological bases of the heart innervation. M.: Nauka, 1992. 366 p.Shvalev V.N., Sosunov A.A., Guski G. The morphological bases of the heart innervation. M.: Nauka, 1992. 366 p.Shvalev V.N., Tarskij N.A. The phenomenon of early age involution of sympathetic nervous system, Kardiologija. 2001. No. 2. P. 10-14.Shvalev V.N., Tarskij N.A. The phenomenon of early age involution of sympathetic nervous system, Kardiologija. 2001. No. 2. P. 10-14.Docherty J.R. Autonomic neuroscience, Basic and Clinical. 2002, Vol. 96. P. 8-12.Docherty J.R. Autonomic neuroscience, Basic and Clinical. 2002, Vol. 96. P. 8-12.Esler M.D., Tumer A.G., Kaye D.M. et al. Aging effects on human sympathetic neuronal function, Am. J. Physiol., 1995, Vol. 268. P. 278-285.Esler M.D., Tumer A.G., Kaye D.M. et al. Aging effects on human sympathetic neuronal function, Am. J. Physiol., 1995, Vol. 268. P. 278-285.Feron O., Belhassen L., Kobzik L. et al. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells, J. Biol. Chem. 1996. Vol. 271, No. 37. P 22810-22814.Feron O., Belhassen L., Kobzik L. et al. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells, J. Biol. Chem. 1996. Vol. 271, No. 37. P 22810-22814.Forstermann U., Boissel J.P, Kleinert H. Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III), FASEB J. 1998. Vol. 12, No. 10. P 773-790.Forstermann U., Boissel J.P, Kleinert H. Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III), FASEB J. 1998. Vol. 12, No. 10. P 773-790.Fukuchi M., Hussain S.N.A., Giaid A. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure, Circulation. 1998. Vol. 98, No. 2. P. 132-139.Fukuchi M., Hussain S.N.A., Giaid A. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure, Circulation. 1998. Vol. 98, No. 2. P. 132-139.Gallo M.P., Malan D., Bedendi I. et al. Regulation of cardiac calcium current by NO and cGMP-modulating agents, Pflugers Arch. 2001. Vol. 441, No. 5. Р 621-628.Gallo M.P., Malan D., Bedendi I. et al. Regulation of cardiac calcium current by NO and cGMP-modulating agents, Pflugers Arch. 2001. Vol. 441, No. 5. Р 621-628.Gray A.L., Johnson Т.А., Lauenstein J.-M. et al. Parasympathetic control of the heart, Journal Appl. Physiol. 2004. Vol. 96. P. 2279-2287.Gray A.L., Johnson Т.А., Lauenstein J.-M. et al. Parasympathetic control of the heart, Journal Appl. Physiol. 2004. Vol. 96. P. 2279-2287.Guski H., Shvalev V.N., Kapelko V.I. Studies on the neurogenic pathogenesis of cardiomyopathy, II Florence Meeting on advances in cardiomyopathies. Florence, Italy, 1997. P. 24.Guski H., Shvalev V.N., Kapelko V.I. Studies on the neurogenic pathogenesis of cardiomyopathy, II Florence Meeting on advances in cardiomyopathies. Florence, Italy, 1997. P. 24.Ostadal В., Nagano M., Takeda N., Dhalla N.S. The developing Heart. New York: Lippincott-Raven Publ. Philadelphia, 1997, 501 p.Ostadal В., Nagano M., Takeda N., Dhalla N.S. The developing Heart. New York: Lippincott-Raven Publ. Philadelphia, 1997, 501 p.

The authors declare that there are no conflicts of interest present.