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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-941</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Апоптоз как фактор организации посттравматического воспаления</article-title><trans-title-group xml:lang="en"><trans-title>Apoptosis as factor of post-injury inflammation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Едранов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Edranov</surname><given-names>S. S.</given-names></name></name-alternatives><email xlink:type="simple">mobilestom@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2012</year></pub-date><volume>0</volume><issue>2</issue><fpage>100</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Едранов С.С., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Едранов С.С.</copyright-holder><copyright-holder xml:lang="en">Edranov S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/941">https://www.tmj-vgmu.ru/jour/article/view/941</self-uri><abstract><p>Обзор литературы, посвященный механизмам запрограммированной гибели клетки - апоптозу. Рассматриваются морфология апоптоза и некроза, факторы, активирующие и подавляющие эти процессы, роль апоптоза и некроза в воспалительных реакциях и регенерации.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents overview of literature dedicated to the mechanisms of programmed cell death (apoptosis) and considers morphology of apoptosis and necrosis, factors known to activate and suppress these processes, and role of apoptosis and necrosis in inducing inflammatory responses and regeneration.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>апоптоз</kwd><kwd>некроз</kwd><kwd>повреждение</kwd><kwd>регенерация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>apoptosis</kwd><kwd>necrosis</kwd><kwd>lesion</kwd><kwd>regeneration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bakeeva L.E. The ultrastructure of mitochondria under apoptosis, Citologija. 2003. Vol. 45, No. 9. p. 847-848.</mixed-citation><mixed-citation xml:lang="en">Bakeeva L.E. The ultrastructure of mitochondria under apoptosis, Citologija. 2003. Vol. 45, No. 9. p. 847-848.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Domnina L.V., Ivanova O.Ju., Fetisova E.A. et al. The marginal blebbing as an early manifestation of apoptosis induced by TNF, Citologija. 2003. Vol. 45, No. 9. P. 870-871.</mixed-citation><mixed-citation xml:lang="en">Domnina L.V., Ivanova O.Ju., Fetisova E.A. et al. The marginal blebbing as an early manifestation of apoptosis induced by TNF, Citologija. 2003. Vol. 45, No. 9. P. 870-871.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kalinichenko S.G., Matveeva N.Ju. The morphological characteristics of apoptosis and its role in neurogenesis, Morfologija. 2007. Vol. 131, No. 2. P 16-28.</mixed-citation><mixed-citation xml:lang="en">Kalinichenko S.G., Matveeva N.Ju. The morphological characteristics of apoptosis and its role in neurogenesis, Morfologija. 2007. Vol. 131, No. 2. P 16-28.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lushnikov E.F., Abrosimov A.Ju. Cell death (apoptosis). M.: Medicina, 2001. 190 p.</mixed-citation><mixed-citation xml:lang="en">Lushnikov E.F., Abrosimov A.Ju. Cell death (apoptosis). M.: Medicina, 2001. 190 p.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Matveeva N.Ju. The apoptosis and nitric oxide in the development of retinal neurons. Vladivostok: Medicina DV, 2006. 215 p.</mixed-citation><mixed-citation xml:lang="en">Matveeva N.Ju. The apoptosis and nitric oxide in the development of retinal neurons. Vladivostok: Medicina DV, 2006. 215 p.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Matveeva N.Ju., Kalinichenko S.G., Puwin I.I., Motavkin P.A. The role of nitric oxide in apoptosis of human fetal retinal neurons, Morfologija. 2006. Vol. 123, No. 1. P. 40-49.</mixed-citation><mixed-citation xml:lang="en">Matveeva N.Ju., Kalinichenko S.G., Puwin I.I., Motavkin P.A. The role of nitric oxide in apoptosis of human fetal retinal neurons, Morfologija. 2006. Vol. 123, No. 1. P. 40-49.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Palcev M.A. The molecular basis of apoptosis, Vestnik RAMN. 2002. Vol. 72, No. 1. P 13-21.</mixed-citation><mixed-citation xml:lang="en">Palcev M.A. The molecular basis of apoptosis, Vestnik RAMN. 2002. Vol. 72, No. 1. P 13-21.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Filchenkov A.A. Caspases: regulators of apoptosis and other cellular functions, Biohimija. 2003. No. 68. P. 453-466.</mixed-citation><mixed-citation xml:lang="en">Filchenkov A.A. Caspases: regulators of apoptosis and other cellular functions, Biohimija. 2003. No. 68. P. 453-466.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Jarilin A.A. Apoptoz. The nature of the phenomenon and its role in the whole organism, Pat. fiziol. 1998. No. 2. P 38-48.</mixed-citation><mixed-citation xml:lang="en">Jarilin A.A. Apoptoz. The nature of the phenomenon and its role in the whole organism, Pat. fiziol. 1998. No. 2. P 38-48.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chae I.H., Park K.W., Kim H.S., Oh B.H. Nitric oxide-induced apoptosis is mediated by Bax/Bcl-2 gene expression, transition of cytochrome c, and activation of caspase-3 in rat vascular smooth muscle cells, Clin. Chim. Acta. 2004. Vol. 341. P. 83-91.</mixed-citation><mixed-citation xml:lang="en">Chae I.H., Park K.W., Kim H.S., Oh B.H. Nitric oxide-induced apoptosis is mediated by Bax/Bcl-2 gene expression, transition of cytochrome c, and activation of caspase-3 in rat vascular smooth muscle cells, Clin. Chim. Acta. 2004. Vol. 341. P. 83-91.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chung E.Y., Kim S.J., Ma X.J. Regulation of cytokine production during phagocytosis of apoptotic cells, Cell Res. 2006. Vol. 16. P 154-161.</mixed-citation><mixed-citation xml:lang="en">Chung E.Y., Kim S.J., Ma X.J. Regulation of cytokine production during phagocytosis of apoptotic cells, Cell Res. 2006. Vol. 16. P 154-161.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen J.J. Apoptosis: the physiologic pathway of cell death, Hosp. Pract. 1993. Vol. 28. P. 35-43.</mixed-citation><mixed-citation xml:lang="en">Cohen J.J. Apoptosis: the physiologic pathway of cell death, Hosp. Pract. 1993. Vol. 28. P. 35-43.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ferri K. Apoptosis control in syncytia induced by thy HIV type 1-envelope glycoprotein complex, role of mitochondria and caspase, J. Exp. Med. 2000. Vol. 192. P 1081-1092.</mixed-citation><mixed-citation xml:lang="en">Ferri K. Apoptosis control in syncytia induced by thy HIV type 1-envelope glycoprotein complex, role of mitochondria and caspase, J. Exp. Med. 2000. Vol. 192. P 1081-1092.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hengarten O.M. The biochemistry of apoptosis, Nature. 2000. Vol. 407. P. 770-775.</mixed-citation><mixed-citation xml:lang="en">Hengarten O.M. The biochemistry of apoptosis, Nature. 2000. Vol. 407. P. 770-775.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ho P.K., Hawkins C.J. Mammalian initiator apoptotic caspases, FEBS J. 2005. Vol. 272. P. 5436-5453.</mixed-citation><mixed-citation xml:lang="en">Ho P.K., Hawkins C.J. Mammalian initiator apoptotic caspases, FEBS J. 2005. Vol. 272. P. 5436-5453.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Horky M., Kotala V., Anton M. et al. Nucleolus and apoptosis, Ann. N.Y. Acad. Sci. 2002. Vol. 973. P 258-264.</mixed-citation><mixed-citation xml:lang="en">Horky M., Kotala V., Anton M. et al. Nucleolus and apoptosis, Ann. N.Y. Acad. Sci. 2002. Vol. 973. P 258-264.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ju E.J., Kwak D.H., Lee D.H. et al. Pathophysiological implication of ganglioside GM3 in early mouse embryonic development through apoptosis, Arch. Pharm. Res. 2005. Vol. 28. P. 1057-1064.</mixed-citation><mixed-citation xml:lang="en">Ju E.J., Kwak D.H., Lee D.H. et al. Pathophysiological implication of ganglioside GM3 in early mouse embryonic development through apoptosis, Arch. Pharm. Res. 2005. Vol. 28. P. 1057-1064.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kuida K., Haydar T., Kuan C. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9, Cell. 1998. Vol. 94. P 352-337.</mixed-citation><mixed-citation xml:lang="en">Kuida K., Haydar T., Kuan C. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9, Cell. 1998. Vol. 94. P 352-337.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Meier P., Finch A., Evan G. Apoptosis in development, Nature. 2000. Vol. 407. P. 796-801.</mixed-citation><mixed-citation xml:lang="en">Meier P., Finch A., Evan G. Apoptosis in development, Nature. 2000. Vol. 407. P. 796-801.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Moll U.M., Zaika A. Nuclear and mitochondrial apoptotic pathways of p53, FEBS Lett. 2001. Vol. 493. P 65-69.</mixed-citation><mixed-citation xml:lang="en">Moll U.M., Zaika A. Nuclear and mitochondrial apoptotic pathways of p53, FEBS Lett. 2001. Vol. 493. P 65-69.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Muresanu D.F. Neurotrophic factors. Bucuresti: Libripress, 2003. 464 p.</mixed-citation><mixed-citation xml:lang="en">Muresanu D.F. Neurotrophic factors. Bucuresti: Libripress, 2003. 464 p.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Neary J.T., Zimmermann H. Trophic functions of nucleotides in the central nervous system, Trends Neurosci. 2009. Vol. 32. P. 189-198.</mixed-citation><mixed-citation xml:lang="en">Neary J.T., Zimmermann H. Trophic functions of nucleotides in the central nervous system, Trends Neurosci. 2009. Vol. 32. P. 189-198.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Niidome T., Morimoto N., Iijima S. et al. Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation, Eur. J. Pharmacol. 2006. Vol. 548. P. 1-8.</mixed-citation><mixed-citation xml:lang="en">Niidome T., Morimoto N., Iijima S. et al. Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation, Eur. J. Pharmacol. 2006. Vol. 548. P. 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Oppenheim R.W. Programmed cell death, Fundamental Neuroscience / Zigmond M.J., Bloom F.E., Roberts J.L. et al. eds. San Diego: Academic, 1999. P 581-609.</mixed-citation><mixed-citation xml:lang="en">Oppenheim R.W. Programmed cell death, Fundamental Neuroscience / Zigmond M.J., Bloom F.E., Roberts J.L. et al. eds. San Diego: Academic, 1999. P 581-609.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Perecko T., Drabikova K., Rackova L. et al. Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro, Neuroendocrinol. Lett. 2010. Vol. 28. P. 34-38.</mixed-citation><mixed-citation xml:lang="en">Perecko T., Drabikova K., Rackova L. et al. Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro, Neuroendocrinol. Lett. 2010. Vol. 28. P. 34-38.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Skulachev V.P., Bakeeva L.E., Chernyak B.V. et al. Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis, Mol. Cell Biochem. 2004. Vol. 256-257. P. 341-358.</mixed-citation><mixed-citation xml:lang="en">Skulachev V.P., Bakeeva L.E., Chernyak B.V. et al. Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis, Mol. Cell Biochem. 2004. Vol. 256-257. P. 341-358.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Sloviter R. Apoptosis: a guide for perplexed, Trends Pharmacol. Sci. 2002. Vol. 23. P. 19-24.</mixed-citation><mixed-citation xml:lang="en">Sloviter R. Apoptosis: a guide for perplexed, Trends Pharmacol. Sci. 2002. Vol. 23. P. 19-24.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Van Delft M.F., Huang D.C. How the Bcl-2 family of proteins interact to regulate apoptosis, Cell Res. 2006. Vol. 16. P 203-213.</mixed-citation><mixed-citation xml:lang="en">Van Delft M.F., Huang D.C. How the Bcl-2 family of proteins interact to regulate apoptosis, Cell Res. 2006. Vol. 16. P 203-213.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Yan N., Shi Y. Mechanisms of apoptosis through structural biology, Annu. Rev. Cell Dev. Biol. 2005. Vol. 21. P 35-56.</mixed-citation><mixed-citation xml:lang="en">Yan N., Shi Y. Mechanisms of apoptosis through structural biology, Annu. Rev. Cell Dev. Biol. 2005. Vol. 21. P 35-56.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J., Dawson V.L., Dawson T.M., and Snyder S.H. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity, Science. 1994. Vol. 263. P. 687-689.</mixed-citation><mixed-citation xml:lang="en">Zhang J., Dawson V.L., Dawson T.M., and Snyder S.H. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity, Science. 1994. Vol. 263. P. 687-689.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
