pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-962Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESНитроксидсинтаза тучных клеток слизистой оболочки максиллярной пазухи крыс при травме верхнечелюстного нерваNitric oxide synthases of mast cells of mucous coat of rat’s maxillary sinus in case of maxillary nerve injuryЕдрановС. С.EdranovS. S.mobilestom@yandex.ruВладивостокский государственный медицинский университетРоссияVladivostok State Medical UniversityRussian Federation201128122011045356Copyright © Едранов С.С., 20112011Едранов С.С.Edranov S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/962

Представлены результаты изучения локализации нитроксидсинтазы в тучных клетках слизистой оболочки максиллярной пазухи 15 половозрелых крыс в условиях экспериментальной травмы верхнечелюстного нерва. Показано, что формирование очагов повреждения в слизистой оболочке в результате деафферентации возникало в ближайший период после травмы. Тучные клетки экспрессировали индуцибельную нитроксид- синтазу и претерпевали дегрануляцию на стороне повреждения. Делается заключение, что нитроксидсинтезирующие тучные клетки опосредуют трофические (протективные) и/или токсические эффекты оксида азота в период восстановления после экспериментальной травмы верхнечелюстного нерва.

The paper provides results of research into localisation of nitric oxide synthase in mast cells of mucous coat of 15 sexually mature rats under the conditions of experimental injury of maxillary nerve, and indicates that the lesions in the mucous coat have resulted from deafferentation occurred right after the injury. The mast cells produced nitric oxide synthase and degranulated in the area of the injury. The authors consider that the nitric oxide synthase-inducing mast cells mediate the trophic (protective) and/or toxic effects from the nitric oxide during reconvalescence period after the experimental injury of the maxillary nerve.

оксид азотаслизистая оболочкадеафферентацияnitric oxidemucous membranedeafferentationReferencesЗуга М.В., Мотавкин П.А. Морфологические основы холинореактивности тучных клеток органов дыхания// Морфология. 1998. Т. 114, № 4. С. 72-77.Зуга М.В., Мотавкин П.А. Морфологические основы холинореактивности тучных клеток органов дыхания// Морфология. 1998. Т. 114, № 4. С. 72-77.Choi B.M., Pae H.O., Jang S.I. et al. Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator// J. Biochem. Mol. Biol. 2002. Vol. 35, No. 1. P. 116-126.Choi B.M., Pae H.O., Jang S.I. et al. Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator// J. Biochem. Mol. Biol. 2002. Vol. 35, No. 1. P. 116-126.Crosswhite P., Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension // J. Hypertens. 2010. Vol. 28, No. 2. P. 201-212.Crosswhite P., Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension // J. Hypertens. 2010. Vol. 28, No. 2. P. 201-212.Estévez A.G., Jordân J. Nitric oxide and superoxide, a deadly cocktail // Ann. NY Acad. Sci. 2002. Vol. 962, No. 3. P. 207-211.Estévez A.G., Jordân J. Nitric oxide and superoxide, a deadly cocktail // Ann. NY Acad. Sci. 2002. Vol. 962, No. 3. P. 207-211.Galli S.J., Tsai M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity // Eur. J. Immunol. 2010. Vol. 40, No. 7. P. 1843-1851.Galli S.J., Tsai M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity // Eur. J. Immunol. 2010. Vol. 40, No. 7. P. 1843-1851.Horny H.P., Sotlar K., Valent P. Differential diagnoses of systemic mastocytosis in routinely processed bone marrow biopsy specimens: a review // Pathobiology 2010. Vol. 77, No. 4. P. 169-180.Horny H.P., Sotlar K., Valent P. Differential diagnoses of systemic mastocytosis in routinely processed bone marrow biopsy specimens: a review // Pathobiology 2010. Vol. 77, No. 4. P. 169-180.Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). 2008. Vol. 291, No. 11. P. 1479-1484.Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). 2008. Vol. 291, No. 11. P. 1479-1484.Malinski T., Taha Z., Grunfeld S. Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors // Biochem. Biophys. Res. Comm. 1993. Vol. 193, No. 7. P. 1076-1082.Malinski T., Taha Z., Grunfeld S. Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors // Biochem. Biophys. Res. Comm. 1993. Vol. 193, No. 7. P. 1076-1082.Niidome T., Morimoto N., Iijima S. et al. Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation // Eur. J. Pharmacol. 2006. Vol. 548, No. 1-3. P. 1-8.Niidome T., Morimoto N., Iijima S. et al. Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation // Eur. J. Pharmacol. 2006. Vol. 548, No. 1-3. P. 1-8.Sànchez C.A., Hallberg J., Lundberg J. O. et al. Nasal nitric oxide and regulation of human pulmonary blood flow in the upright position // J. Appl. Physiol. 2010. Vol. 108, No. 1. P. 181-188.Sànchez C.A., Hallberg J., Lundberg J. O. et al. Nasal nitric oxide and regulation of human pulmonary blood flow in the upright position // J. Appl. Physiol. 2010. Vol. 108, No. 1. P. 181-188.Tham C.L., Liew C.Y., Lam K.W. et al. A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis // Eur. J. Pharmacol. 2010. Vol. 628, No. 1-3. P. 247-254.Tham C.L., Liew C.Y., Lam K.W. et al. A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis // Eur. J. Pharmacol. 2010. Vol. 628, No. 1-3. P. 247-254.Thermos K. Novel signals mediating the functions of somatostatin: the emerging role of NO/cGMP // Mol. Cell Endocrinol. 2008. Vol. 286, No. 1-2. P. 49-57.Thermos K. Novel signals mediating the functions of somatostatin: the emerging role of NO/cGMP // Mol. Cell Endocrinol. 2008. Vol. 286, No. 1-2. P. 49-57.Tzeng S.F., Huang H.Y. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia // J. Cell. Biochem. 2003. Vol. 90, No. 2. P. 227-233.Tzeng S.F., Huang H.Y. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia // J. Cell. Biochem. 2003. Vol. 90, No. 2. P. 227-233.Weinberger B., Fakhrzadeh L., Heck D.E. et al. Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates // Am. J. Respir. Crit. Care Med. 1998. Vol. 158, No. 3. P. 931-938.Weinberger B., Fakhrzadeh L., Heck D.E. et al. Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates // Am. J. Respir. Crit. Care Med. 1998. Vol. 158, No. 3. P. 931-938.

The authors declare that there are no conflicts of interest present.