In the article we presented the dates of Clinical and Economic Analysis of the medicinal nomenclature for preferential categories of citizens who need of social support. Methods. The aim of our study is to analyse the rationality of medicinal structure and to compare it with The List of Vital and Necessary Medicines of Russian Federation. We studied the structure of medicinal purchases with the help of ABC VEN-analysis. We accentuated VEN-analysis that evaluated expenses for significant medicines. Results. The study has demonstrated that 112 from 150 medicines (74,7 %) were attributed to class V (vital medicines) by VEN-analysis, 25 from 150 medicines (16,7 %) were attributed to class E (essential medicines) and only 13 from 150 medicines (8,6 %) were attributed to class N (non-essential medicines). In the analysis of the range of medicinal nomenclature for compliance with the List of Vital and Essential Medicines in accordance with Annex № 2 to the Order of the Government of the Russian Federation dated 30 December 2014 No. 2782-r found that savings, which in itself carries the adoption of the order of 1,676,811.40 rubles by reducing the number of medicines with low or unproven therapeutic efficacy. Conclusions. According to our research the medicinal nomenclature was rational. The feasibility of utilization of financial resources and the priority of vital medicines is dictated by the principles of evidence-based medicine, contributing to a rational choice of medicines in each clinical case. Accepted Government Decree № 2782-r will in the future save money by avoiding medicines with unproven efficacy and direct means for highly efficient and safe medicines.