Role of matrix metalloproteinases in forming morphofunctional imbalance of airways in case of chronic obstructive lung disease
Abstract
The authors deem the chronic obstructive lung disease to be nicotine-associated disease that mostly results from the imbalance in the ‘proteolysis-antiproteolysis’ system. The matrix metalloproteinases are independent factors that play an important role in forming respiratory ways inflammation. From the present-day standpoint of the pathogenesis of chronic obstructive lung disease, the authors consider the role of various representatives of the matrix metalloproteinases’ class and summarise the current data about the independent action of these enzymes on the pulmonary tissue, and their important function in the progradient course of the inflammatory response in the respiratory ways.
About the Authors
V. A. Nevzorova
Vladivostok State Medical University
Russian Federation
Russian Federation
T. V. Tilik
Vladivostok State Medical University
Russian Federation
Russian Federation
E. A. Gilifanov
Vladivostok State Medical University
Russian Federation
Russian Federation
E. A. Panchenko
Vladivostok State Medical University
Russian Federation
Russian Federation
S. E. Vakhrusheva
Vladivostok State Medical University
Russian Federation
Russian Federation
V. V. Tilik
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Nevzorova V.A., Tilik T.V., Gilifanov E.A., Panchenko E.A., Vakhrusheva S.E., Tilik V.V. Role of matrix metalloproteinases in forming morphofunctional imbalance of airways in case of chronic obstructive lung disease. Pacific Medical Journal. 2011;(2):9-13. (In Russ.)
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