The state of systemic and local immune response in case of community-acquired pneumonia of different aetiology
Abstract
On examining 118 patients with the community-acquired pneumonia caused by various pathogens, the authors estimated the receptor activity of immune competent cells of peripheral blood, induced sputum and mucous tunic of large bronchi. To identify cells, the authors used monoclonal antibodies. There were unidirectional changes like lowering receptor activity in 6 and 7 of 9 cell populations under study, respectively. Also, there were differences in the state of excitatory cells of the peripheral blood and in the induced sputum, depending on pneumonia aetiology. The immune competent cells of the mucous tunic of bronchi were characterised by stability in the state of receptor activity. These indices almost coincided with the control ones.
About the Authors
N. V. Shestakova
Vladivostok State Medical University
Russian Federation
Russian Federation
V. A. Nevzorova
Vladivostok State Medical University
Russian Federation
Russian Federation
T. F. Borovskaya
Khabarovsk Branch of Russian Oncological Centre, RAMS
Russian Federation
Russian Federation
L. D. Skrebkova
Yuzhno-Sakhalinsk Municipal Hospital
Russian Federation
Russian Federation
T. B. Dmitrieva
Yuzhno-Sakhalinsk Municipal Hospital
Russian Federation
Russian Federation
References
1. Боровская Т.Ф., Когут Е.П., Курпас Э.Х. Особенности иммунного ответа у больных с внебольничной пневмонией // Бюл. физиол. и патол. дыхания. 2004. Вып. 17. С. 77-79.
2. Земсков А.М. Клиническая иммунология. М.: ГЭОТАР-Медиа, 2008. 432 с.
3. Маянский А.Н. Лекции по иммунологии. Н. Новгород: НГМА, 2003. 272 с.
4. Рабсон Л., Ройт А., Делвиз П. Основы медицинской иммунологии / пер. с англ. М.: Мир, 2006. 320 с.
5. Синопальников А.И., Козлов Р.С. Внебольничные инфекции дыхательных путей: руководство для врачей. М.: Премьер МТ, 2007. 352 с.
6. Хаитов Р.М. Иммунология. М.: ГЭОТАР-Медиа, 2009. 320 с.
7. Хаитов Р.М., Пинегин Б.В., Ярилин А.А. Руководство по клинической иммунологии. Диагностика заболеваний иммунной системы. М.: ГЭОТАР-Медиа, 2009. 352 с.
8. Чернушенко Е.Ф. Диагностика вторичных иммунодефицитных состояний // Искусство лечения. 2006. № 2 (28). С. 5-12.
9. Чучалин А.Г. Пневмония. М.: Экономика и информатика, 2002. 180 с.
10. Immunology, 6th ed., Garland Science, New York-London, 2005.
11. Kohlmeier J.E., Woodland D.L. Memory T-cell recruitment to the lung airways // Curr. opin. immunol. 2006. Vol. 18, No. 3. P. 357-362.
12. Roberts A.D., Woodland D.L. Effector memory CD8+ T-cells play a prominent role in recall responses to secondary viral infection in the lung// J. Immunol. 2004. Vol. 172, No. 11. Р 6533-6537.
13. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses // Annu. Rev. Immunol. 2004. No. 22. Р 531- 562.
Review
For citations:
Shestakova N.V., Nevzorova V.A., Borovskaya T.F., Skrebkova L.D., Dmitrieva T.B. The state of systemic and local immune response in case of community-acquired pneumonia of different aetiology. Pacific Medical Journal. 2011;(2):74-77. (In Russ.)
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