Trophic factors of bone growth, their morphogenetic characterization and clinical significance
https://doi.org/10.17238/PmJ1609-1175.2017.1.10-16
Abstract
The literature review dedicated to regeneration mechanisms of bone tissue. Summarized the data on topochemistry and functions of morphogenetic and growth factors, their participation in the regulation of the regenerative processes on different levels of the fracture union. Given the detailed critical overview of the technologies of production and clinical use of morphogenetic proteins on the basis of recombinant technologies of gene engineering with reparative osseogenesis. One of the most promising ways of increasing the osteoinductive properties of biomaterials and bone tissue regeneration control process is the creation of various composites having osteoinductive and osteoconductive properties, containing growth factors, and at the same time performing the role of the osteogenic matrix.
About the Authors
R. E. Kostiv
Pacific State Medical University
Russian Federation
Russian Federation
S. G. Kalinichenko
Pacific State Medical University
Russian Federation
Russian Federation
N. Yu. Matveeva
Pacific State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kostiv R.E., Kalinichenko S.G., Matveeva N.Yu. Trophic factors of bone growth, their morphogenetic characterization and clinical significance. Pacific Medical Journal. 2017;(1):10-16. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2017.1.10-16
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