Биомаркеры и участники ремоделирования субхондральной кости при остеоартрозе
https://doi.org/10.17238/PmJ1609-1175.2017.1.37-41
Аннотация
Остеоартроз (ОА) - наиболее распространенное и социально значимое заболевание опорно-двигательного аппарата, основной проблемой лечения которого является отсутствие диагностических и прогностических маркеров ранних стадий заболевания. Цель этого обзора - анализ данных о биомаркерах деградации субхондральной кости при ОА. Рассматриваются субфенотипические молекулы - холекальциферол и паратиреоидный гормон, а также биологические субстанции, образующиеся остеобластами на разных стадиях костной дифференцировки. Обзор литературы позволяет предположить важное диагностическое значение при ОА целого ряда биологических субстанций, среди которых наибольший интерес представляют остеокальцин, кальцитонин, продукты деградации фибриллярных белков костного и хрящевого матрикса, холекальциферол. Перспективным видится исследование диагностической значимости описанных биологических маркеров, что в значительной степени будет способствовать расширению диагностического и прогностического инструментария и поможет более подробно оценивать неоднородную популяцию больных ОА.
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Рецензия
Для цитирования:
Кабалык М.А. Биомаркеры и участники ремоделирования субхондральной кости при остеоартрозе. Тихоокеанский медицинский журнал. 2017;(1):36-41. https://doi.org/10.17238/PmJ1609-1175.2017.1.37-41
For citation:
Kabalyk M.A. Biomarkers of subchondral bone remodeling in osteoarthritis. Pacific Medical Journal. 2017;(1):36-41. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2017.1.37-41
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