THE ROLE OF MONOCYTES/MACROPHAGES IN PATHOGENESIS OF VIRAL INFECTION
Abstract
Review is dedicated to actual question of the monocyting
derivative cells participation in development of viral infection.
These cells can realize positive antiviral effect, which include
the ingesting, killing and elimination of viruses and infecting cells.
Herewith monocytes/macrophages are actuated and produced of
cytokine. Aside from this, these cells can possess and negative influence,
when are occur the dissemination of phagocyting these
viruses in different organs and, hereunder, the formation of new
local inflammation foci. For this reason appears as depression of
cells functional activity, so and manifestation of undesirable consequence
their overweening activation, as follows, they can destroy
the sound cells in inflammation foci, produced the active
radicals of the oxygen and nitric oxide.
derivative cells participation in development of viral infection.
These cells can realize positive antiviral effect, which include
the ingesting, killing and elimination of viruses and infecting cells.
Herewith monocytes/macrophages are actuated and produced of
cytokine. Aside from this, these cells can possess and negative influence,
when are occur the dissemination of phagocyting these
viruses in different organs and, hereunder, the formation of new
local inflammation foci. For this reason appears as depression of
cells functional activity, so and manifestation of undesirable consequence
their overweening activation, as follows, they can destroy
the sound cells in inflammation foci, produced the active
radicals of the oxygen and nitric oxide.
About the Authors
Н. Плехова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
Л. Сомова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
N. G. Plekhova
Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
L. M. Somova
Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
References
1. Гамалей И.Ф., Клюбин И.В. Перекись водорода как сигнальная молекула // Цитология. 1996. Т. 38, № 12. С. 1223-1247.
2. Литвитский П.Ф., Синельникова Т.Г. Врожденный иммунитет: механизмы реализации и патологические синдромы // Вопросы современной педиатрии. 2009. Т. 8. С. 95-101.
3. Пирогова Н.П., Михайлова О.В., Карпова М.Р. и др. Особенности фагоцитарной активности лейкоцитов в периферической крови у больных клещевым энцефалитом // Бюллетень экспериментальной биологии и медицины. 2002. Прил. 1. С. 82-85.
4. Плехова Н.Г. Ультраструктурная и цитохимическая характеристика макрофагов, инфицированных РНК-содержащими вирусами: дис. д-ра биол. наук, 2009. 350 с.
5. Тотолян А.А., Фрейдлин И.С. Клетки иммунной системы. СПб: Наука, 2000. 220 с.
6. Baskin H.S. Herpes simplex virus type 2 synergizes with interferon- y in the induction of nitric oxide production in mouse macrophages through autocrine secretion of tumour necrosis factor- // Gen. Virol. 1997. Vol. 78. P. 195-203.
7. Belge K.U., Dayyani F., Horelt A. et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF // J. Immunol. 2002. Vol. 168. P. 3536-3542.
8. Bergelson J.M., Cunningham J.A., Droguett G. et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 // Science. 1997. Vol. 275. P. 1320-1323.
9. Blond D., Raoul H., Grand R., Dormont D. Nitric oxide synthesis enhances human immunodeficiency virus replication in primary human macrophages // J. Virol. 2000. Vol. 74, No. 19. Р. 8904-8912.
10. Chaturvedi U.C., Nagar R., Shrivastava R. Macrophage & Dengue virus: Friend or foe? // Ind. J. Med. Res. 2006. Vol. 124. P. 23-40.
11. Chen Y.-C., Wang S.-Y. Activation of terminally differentiated human monocytes/macrophages by dengue virus: productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharide // J. Virol. 2002. Vol. 76. P. 9877-9887.
12. Coleman C.M., Wu L. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs // Retrovirology. 2009. Vol. 6. P. 51-62.
13. Fang F.C., Vazquez-Torres A. Nitric oxide production by human macrophages: there›s NO doubt about it // Am. J. Physiol. Lung Cell. Mol. Physiol. 2002. Vol.282, No. 5. Р. 941-943.
14. Feldmann H., Bugany H., Mahner F. et al. Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages // J. Virol. 1996. Vol. 70, No. 4. P. 2208-2214.
15. Freistadt M.S., Eberle K.E. Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication J. Virol. 1996. Vol. 70. P. 6486-6492.
16. Gavrilovskaya I.N., E.J. Brown, M.H. Ginsberg et al. Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins // J. Virol. 1999. Vol. 73, No. 5. P. 3951-3959.
17. Greenberg S., Grinstein S. Phagocytosis and innate immunity // Curr. Opin. Immunol. 2002. Vol. 14. P.136 145.
18. Helmy K.Y., Katschke K.J. Jr., Gorgani N.N. et al. CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens // Cell. 2006. Vol. 124. P. 915-927.
19. Jin M., Park J., Lee S. et al. Hantaan virus enters cells by clathrindependent receptor-mediated endocytosis // Virol. 2002. Vol. 294, No. 1. P. 60-69.
20. Kreil T.R., Eible M.M. Nitric oxide and viral infection: NO antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo // Virol. 1996. Vol. 219. P. 304-306.
21. Li E., Stupack D., Bokoch G.M., Nemerow G.R. Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases // J. Virol. 1998. Vol. 72. P. 8806-8812.
22. Markotić A., Hensley L., Daddario K. et al. Pathogenic hantaviruses elicit different immunoreactions in THP-1 cells and primary monocytes and induce differentiation of human monocytes to dendritic-like cell // Coll. Antropol. 2007. Vol. 31, No. 4. P. 1159-1167.
23. Nauwynck H.J., Duan X., Favoreel H.W. et al. Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis // J. General. Virol. 1999. Vol. 80. P. 297-305.
24. Neves-Souza P.C., Azeredo E.L., Zagne S.M. et al. Kubelka Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection // BMC Infect. Dis. 2005. Vol. 18, No. 5. P. 64-67.
25. Shen J., Devery J.M., King N.J. Adherence status regulates the primary cellular activation responses to the flavivirus West Nile // Immunol. 1995. Vol. 84. P. 254-264.
26. Tuthill T.J., D. Bubeck, D.J. Rowlands, J.M. Hogle Characterization of early steps in the Poliovirus infection process: receptordecorated liposomes induce conversion of the virus to membraneanchored entryintermediate particles // Virol. 2006. Vol. 80, No. 1. P. 172-180.
27. Vuorinen T., Vainionpa R., Heino J., Hyypia T. Coxsackievirus B3 infection in human leukocytes and lymphoid cell lines // J. Gener. Virol. 1999. Vol. 80. P. 921-927
28. Wang H., Ward M. F., Fan X.-G. et al. Potential role of high mobility group box 1 in viral infectious diseases // Viral. Immunol. 2006. Vol.19, No. 1. P. 3-9.
29. Yang K.D., Yeh W.-T., Chen R.-F. et al. Macrophages and other nonspecific defenses: role in modulating resistance against herpes simplex virus // J. Gen. Virol. 2004. Vol. 85. P. 635-642.
30. Ziegler-Heitbrock H.W. Definition of human blood monocytes // J. Leukoc. Biol. 2000. Vol. 67. P. 603-606.
Review
For citations:
, , Plekhova N.G., Somova L.M. THE ROLE OF MONOCYTES/MACROPHAGES IN PATHOGENESIS OF VIRAL INFECTION. Pacific Medical Journal. 2010;(3):5-9. (In Russ.)
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