Analy zing Genomes of Tick-Bone Encephalitis Virus Strains with Various Human Virulence
Abstract
The FE-subtype tick-bone encephalitis strains are capable
of causing disease of various severities. To identify ties between
the disease severity and the virus genome structure, the authors
have detected full-genome nucleotide sequences of strains derived
from both dead persons (high virulent strains) and persons with no
evident symptoms of the disease (unapparent strains). These two
groups of the virus strains were on the phylogenetic tree in different
clusters. Besides, these groups varied by 19 available group-specific
mutant sites in virus proteins. Four mutations caused considerable
changes in the properties of amino acid residues and, were likely to
be key to identify the pathogenicity of the strain.
of causing disease of various severities. To identify ties between
the disease severity and the virus genome structure, the authors
have detected full-genome nucleotide sequences of strains derived
from both dead persons (high virulent strains) and persons with no
evident symptoms of the disease (unapparent strains). These two
groups of the virus strains were on the phylogenetic tree in different
clusters. Besides, these groups varied by 19 available group-specific
mutant sites in virus proteins. Four mutations caused considerable
changes in the properties of amino acid residues and, were likely to
be key to identify the pathogenicity of the strain.
About the Authors
С. Беликов
Лимнологический институт СО РАН
Russian Federation
Russian Federation
Г. Леонова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
И. Кондратов
Лимнологический институт СО РАН
Russian Federation
Russian Federation
Е. Романова
Лимнологический институт СО РАН
Russian Federation
Russian Federation
Е. Павленко
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
S. I. Belikov
Institute of Limnology, SB RAMS
Russian Federation
Russian Federation
G. N. Leonova
Research Institute of Epidemiology and
Microbiology, SB RAMS
Russian Federation
Russian Federation
I. G. Kondratov
Institute of Limnology, SB RAMS
Russian Federation
Russian Federation
E. V. Romanova
Institute of Limnology, SB RAMS
Russian Federation
Russian Federation
E. V. Pavlenko
Research Institute of Epidemiology and
Microbiology, SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
, , , , , Belikov S.I., Leonova G.N., Kondratov I.G., Romanova E.V., Pavlenko E.V. Analy zing Genomes of Tick-Bone Encephalitis Virus Strains with Various Human Virulence. Pacific Medical Journal. 2010;(3):23-26. (In Russ.)
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