Molecular genetic analysis of genome of Glubinnoe/2004 high virulent strain of tick-bone encephalitis
Abstract
The authors present molecular genetic analysis of sequencing
of genome of Glubinnoe/2004 high virulent strain of tickbone
encephalitis (Far Eastern sub-type). Upon comparing this genome
with the genomes of other strains of the Far Eastern, Siberian,
European sub-types, the authors indicate that the Glubinnoy/2004
strain has a number of mutations in the unstructured virus proteins,
virus polyprotein processing sites and promoter sequences of the
genome. These mutations are likely to cause accelerated replication
and maturation of the virus. As shown, the secondary structure of
promotor 5end genome domain and the position of transmembrane
domains in NS2A protein distinguish the FE-subtype strains from
the Siberian and European subtypes of the tick-bone encephalitis.
of genome of Glubinnoe/2004 high virulent strain of tickbone
encephalitis (Far Eastern sub-type). Upon comparing this genome
with the genomes of other strains of the Far Eastern, Siberian,
European sub-types, the authors indicate that the Glubinnoy/2004
strain has a number of mutations in the unstructured virus proteins,
virus polyprotein processing sites and promoter sequences of the
genome. These mutations are likely to cause accelerated replication
and maturation of the virus. As shown, the secondary structure of
promotor 5end genome domain and the position of transmembrane
domains in NS2A protein distinguish the FE-subtype strains from
the Siberian and European subtypes of the tick-bone encephalitis.
Keywords
578.833:57.063.8.575.224.234
About the Authors
Е. Чаусов
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
В. Терновой
ГНЦ вирусологии и биотехнологии "Вектор"
Russian Federation
Russian Federation
Е. Протопопова
ГНЦ вирусологии и биотехнологии "Вектор"
Russian Federation
Russian Federation
Г. Леонова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
В. Локтев
ГНЦ вирусологии и биотехнологии "Вектор"
Russian Federation
Russian Federation
E. V. Chausov
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
V. A. Ternovoy
State Research Centre
of Virology and Biotechnology "Vector"
Russian Federation
Russian Federation
E. V. Protopopova
State Research Centre
of Virology and Biotechnology "Vector"
Russian Federation
Russian Federation
G. N. Leonova
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
V. B. Loktev
State Research Centre
of Virology and Biotechnology "Vector"
Russian Federation
Russian Federation
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Review
For citations:
, , , , , Chausov E.V., Ternovoy V.A., Protopopova E.V., Leonova G.N., Loktev V.B. Molecular genetic analysis of genome of Glubinnoe/2004 high virulent strain of tick-bone encephalitis. Pacific Medical Journal. 2010;(3):27-30. (In Russ.)
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