Left ventricle myocardial hypertrophy: the probability of occurrence and duration

Abstract

Objective. The objective is to determine the probability and time of development of left ventricular myocardial hypertrophy (LVMH), depending on the impact of its predictor. Methods. The study of 2008-2013 involved 7959 workers aged 18-66 years of locomotive brigades of Trans-Baikal Railway, who suffered from cardiovascular diseases with the exception of essential hypertension 1 degree of stage I-II. We searched for risk factors, target lesions of cardiovascular disease with determination from among the predictors of LVMH. Results. In the first stage of research for LVMH established the following predictors: hypertension, age, retinopathy, diabetes, thickening of the complex «intima-media» more than 0.9 mm / atherosclerotic plaques of carotid arteries, body mass index greater than 25, aortic atherosclerosis, hyperglycemia and stress. The second stage was analyzed the survival function. Graphical evaluation of Kaplan-Meier method showed that it was dependent on the body mass index, presence of hypertension, hyperglycemia, retinopathy, arteriosclerosis of the aorta, carotid arteries subclinical and age. Stress as an independent risk factor had no value. Conclusions. Predictors of LVMH in its subclinical characteristics are heterogeneous in size damaging impact, the implementation of progressive course of endothelial dysfunction through an independent impact, or in combination with other predictors. LVMH is determined by the influence of not only traditional risk factors, but also the mutual negative effect of target organ damage.