PATHOMORPHOLOGICAL CHANGES IN CASE OF EXPERIMENTAL TOXEMIA CAUSED BY THERMOLABILE TOXIN YERSINIA PSEUDOTUBERCULOSIS
Abstract
The thermolabile toxin Yersinia pseudotuberculosis is
a species protein with molecular mass of 200 kDa that exhibits
immunogenic and allergic properties and is capable of causing local
dermonecrotic response and laboratory animals death, when
parenterally infused. The paper characterizes pathomorphology
of experimental toxemia caused by intraperitoneal introduction
of this toxin in the concentration of 1.52 mkg/mouse (5 LD50). As
reported, the thermolabile toxin bears direct relation to the progress
of infectious-toxic shock in case of pseudotuberculosis. It
plays key role in causing direct damaging effect on endothelium of
microvessels and cells of parenchymatous organs that tends to be
worsened by circulatory hypoxia. The authors indicate severe dystrophic
and necrotic changes in organs, liver and kidneys mostly,
that are main detoxification barriers when the toxin is introduced
intraperitoneally.
a species protein with molecular mass of 200 kDa that exhibits
immunogenic and allergic properties and is capable of causing local
dermonecrotic response and laboratory animals death, when
parenterally infused. The paper characterizes pathomorphology
of experimental toxemia caused by intraperitoneal introduction
of this toxin in the concentration of 1.52 mkg/mouse (5 LD50). As
reported, the thermolabile toxin bears direct relation to the progress
of infectious-toxic shock in case of pseudotuberculosis. It
plays key role in causing direct damaging effect on endothelium of
microvessels and cells of parenchymatous organs that tends to be
worsened by circulatory hypoxia. The authors indicate severe dystrophic
and necrotic changes in organs, liver and kidneys mostly,
that are main detoxification barriers when the toxin is introduced
intraperitoneally.
Keywords
616-002.71:612.017.4
About the Authors
Л. Сомова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
Н. Плехова
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
Е. Дробот
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
Е. Недашковская
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
Н. Тимченко
НИИ эпидемиологии и микробиологии СО РАМН
Russian Federation
Russian Federation
L. M. Somova
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
N. G. Plekhova
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
E. I. Drobot
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
E. P. Nedashkovskaya
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
N. F. Timchenko
Research Institute of Epidemiology and Microbiology, SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
, , , , , Somova L.M., Plekhova N.G., Drobot E.I., Nedashkovskaya E.P., Timchenko N.F. PATHOMORPHOLOGICAL CHANGES IN CASE OF EXPERIMENTAL TOXEMIA CAUSED BY THERMOLABILE TOXIN YERSINIA PSEUDOTUBERCULOSIS. Pacific Medical Journal. 2010;(3):67-72. (In Russ.)
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