PREPARATIONS OF OMEGA-3 FATTY ACIDS AND THEIR MEDICAL APPLICATION
Abstract
fatty acid preparations available on Russian market and present
situation with their use in medical practice. Information on lipid
composition of 15 preparations is given as well as data on their
main fatty acid. Present situation with scientific investigations
and medical application of omega-3 fatty acid as it looked in top
level scientific journal of the World was analyzed using Web of
Science. It was found that interest to these fatty acid increases
and area of their application is enlarged. Up to now the leading
places in the application are occupied by cardiac and vascular
diseases. Among others areas neural, psychological diseases and
oncology have increased interest to the preparations.
About the Authors
В. ВаськовскийRussian Federation
Т. Горбач
Russian Federation
А. Есипов
Russian Federation
В. Светашев
Russian Federation
М. Яцкова
Russian Federation
V. E. Vaskovsky
Russian Federation
T. A. Gorbach
Russian Federation
A. V. Esipov
Russian Federation
V. I. Svetashev
Russian Federation
M. A. Yatskova
Russian Federation
References
1. Berquin I.M., Edwards I.J., Chen Y.Q. Multi-targeted therapy of cancer by omega-3 fatty acids // Cancer Lett. 2008. Vol. 269, No. 2. P. 363-377.
2. Carreau J.P., Dubacq J.P. Adaptation of macro-scale method to the micro-scale for fatty acid methyl transesterification of biological lipid extracts // J. Chromatogr. 1978. Vol. 151, No. 3. P. 384-390.
3. Hartweg J., Perera R., Montori V. et al. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus // Cochrane Database System. Rev. 2008. No. 1. Art. No. CD003205.
4. Li J.J., Huang C.J., Xie D. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid // Mol. Nutrit. Food Res. 2008. Vol. 52, No. 6. P. 631-645.
5. Milte C.M., Sinn N., Howe P.R.C. Polyunsaturated fatty acid status in attention deficit hyperactivity disorder, depression, and Alzheimer›s disease: towards an omega-3 index for mental health? // Nutrit. Rev. 2009. Vol. 67, No. 10. P. 573-590.
6. Mori T.A., Burke V., Puddey I.B. et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men // Am. J. Clin. Nutr. 2000; Vol.71, No. 5. P. 1085-1094.
7. Osher Y., Belmaker R.H. Omega-3 fatty acids in depression: A review of three studies // CNS Neurosci.Therap. 2009. Vol. 15, No. 2. P. 128-133.
8. Riediger N.D., Othman R.A., Suh M. et al. A systemic review of the roles of n-3 fatty acids in health and disease // J. Am. Diet. Assoc. 2009. Vol. 109, No. 4. P. 668-679.
9. Rupp H. Omacor (Prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia // Adv. Therap. 2009. Vol. 26, No.7. P. 675-690.
10. Salari P., Rezaie A., Larijani B. et al. A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis // Med. Sci. Monitor. 2008. Vol. 14, No. 3. P. RA37-RA44.
11. Simopoulos A.P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases // Expt. Biol. Med. 2008. Vol. 233, No. 6. P. 674-688.
12. Stransky K., Jursik T., Vitek A. Standard equivalent chain length values of monoenic and polyenic fatty acids // J. High Resol. Chromatogr. 1997. Vol. 20, No. 3. P. 143-158.
13. Whelan J. Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty fcid with potential health benefits // J. Nutrit. 2009. Vol. 139, No. 1. P. 5-10.
14. Wojenski C.M., Silver M.J., Wallker J. Eicosapentaenoic acid ethyl- ester as an antithrombotic agent- Comparison to an extract of fish oil // Biochim. Biophys. Acta. 1991. Vol. 1081, No. 1. P. 33-38.
15. Крылов Ю.Ф., Любимов И.Б., Муляр А.Г. Перспективы ис- пользования эйкозапентаеновой и докозагексаеновой кис- лот как лекарственных средств // Химико-фарм. журн. 1991. Т. 25, № 9. С. 4-11.
Review
For citations:
, , , , , Vaskovsky V.E., Gorbach T.A., Esipov A.V., Svetashev V.I., Yatskova M.A. PREPARATIONS OF OMEGA-3 FATTY ACIDS AND THEIR MEDICAL APPLICATION. Pacific Medical Journal. 2010;(2):15-19. (In Russ.)