ИНГИБИРОВАНИЕ ДИФФЕРЕНЦИРОВКИ НЕЙРАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК С ПОМОЩЬЮ БИОПОЛИМЕРНЫХ МАТРИКСНЫХ МАТЕРИАЛОВ
Аннотация
matrix materials being partial structurally-functional analogues
of hyaluronic acid-based glycopolymers. Original modified
polysaccharidic compounds had inhibiting effect on the
capability of neutral stem cells to differentiate. To estimate
cell vitality after cultivation on the substrates under study,
the authors have re-cultivated them under the conditions of
induced adhesion and differentiation. All the studied variants
of glycopolymer matrixes have proved the capability of cells to
differentiate and regular grow under the conditions of neuroinduction
substrate that included dimerous forms of IV type
collagen. One of the materials included modified derivatives
of uronic acids has been recommended as promising matrix
capable of inhibiting undesirable spontaneous differentiation
of neutral stem cells during derivation and conservation of their
biomass needed to create artificial implants of nervous tissue.
Об авторах
В. В. КумейкоРоссия
А. П. Анисимов
Россия
А. В. Щеблыкина
Россия
А. А. Астахова
Россия
Н. Е. Зюмченко
Россия
Н. П. Токмакова
Россия
И. А. Кирсанова
Россия
А. А. Анисимова
Россия
Е. В. Демиденко
Россия
И. В. Дюйзен
Россия
М. Ю. Хотимченко
Россия
V. Kumeiko
Россия
A. Anisimov
Россия
A. Scheblyikina
Россия
A. Astakhova
Россия
N. Zyumchenko
Россия
N. Tokmakova
Россия
I. Kirsanova
Россия
A. Anisimova
Россия
E. Demidenko
Россия
I. Dyuizen
Россия
Yu. Khotimchenko
Россия
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Рецензия
Для цитирования:
Кумейко В.В., Анисимов А.П., Щеблыкина А.В., Астахова А.А., Зюмченко Н.Е., Токмакова Н.П., Кирсанова И.А., Анисимова А.А., Демиденко Е.В., Дюйзен И.В., Хотимченко М.Ю., , , , , , , , , , , ИНГИБИРОВАНИЕ ДИФФЕРЕНЦИРОВКИ НЕЙРАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК С ПОМОЩЬЮ БИОПОЛИМЕРНЫХ МАТРИКСНЫХ МАТЕРИАЛОВ. Тихоокеанский медицинский журнал. 2010;(2):20-26.
For citation:
, , , , , , , , , , , Kumeiko V.V., Anisimov A.P., Scheblyikina A.V., Astakhova A.A., Zyumchenko N.E., Tokmakova N.P., Kirsanova I.A., Anisimova A.A., Demidenko E.V., Dyuizen I.V., Khotimchenko Yu.S. DIFFERENTIATION INHIBITION OF NEUTRAL STEM CELLS VIA BIO-POLYMER MATRIX MATERIALS. Pacific Medical Journal. 2010;(2):20-26. (In Russ.)