Effects of Pectins of Various Molecular Mas On Growth of Ehrlich Adenocarcinoma and Lewis Lung Carcinoma , Cyclophosphan Efficiency in Mice
Abstract
Using models of passaged Ehrlich adenocarcinoma
and Lewis lung carcinoma in mice, the authors have studied
effects of pectins with various molecular mass that were orally
introduced at a dose of 50 and 100 mg/kg. The pectins with
molecular mass of up to 20 kDa induced Ehrlich adenocarcinoma
growth; the 50 mg/kg dose increased antitumor effect of
cyclophosphan. Experiments with Lewis lung carcinoma showed
that all specimens have had no effect on the growth of primary
tumor. This notwithstanding, the pectins with molecular mass
of up to 20 kDa reliably decreased the number of metastatic
focuses and considerably increased anti-metastatic effect of
cyclophosphane.
and Lewis lung carcinoma in mice, the authors have studied
effects of pectins with various molecular mass that were orally
introduced at a dose of 50 and 100 mg/kg. The pectins with
molecular mass of up to 20 kDa induced Ehrlich adenocarcinoma
growth; the 50 mg/kg dose increased antitumor effect of
cyclophosphan. Experiments with Lewis lung carcinoma showed
that all specimens have had no effect on the growth of primary
tumor. This notwithstanding, the pectins with molecular mass
of up to 20 kDa reliably decreased the number of metastatic
focuses and considerably increased anti-metastatic effect of
cyclophosphane.
About the Authors
Т. Разина
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
Е. Зуева
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
Е. Амосова
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
С. Крылова
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
Ю. Хотимченко
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
К. Лопатина
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
Л. Ефимова
НИИ фармакологии СО РАМН
Russian Federation
Russian Federation
T. G. Razina
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
E. P. Zueva
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
E. N. Amosova
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
S. G. Kryilova
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
M. Yu. Khotimchenko
Vladivostok State Medical University
Russian Federation
Russian Federation
K. A. Lopatina
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
L. A. Efimova
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
E. A. Safonova
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
O. Yu. Ryibalkina
Research Institute of Pharmacology, SB RAMS
Russian Federation
Russian Federation
References
1. Афанасьев С.П., Чирва В.Ю., Кацева Г.Н. и др. Модифика- ция титриметрического метода анализа пектиновых ве- ществ // Химия природ. соединений. 1984. № 4. С. 428-431.
2. Оводов Ю.С. Современные представления о пектиновых ве- ществах // Биоорганич. химия. 2009. Т. 35, № 3. С. 293-310.
3. Поддубная И.В. Достижения современной химиотерапии // Современная онкология. 2003. Т. 5, № 2. С. 26-27.
4. Хотимченко Ю.С., Кропотов А.В., Хотимченко М.Ю. Фармакологические свойства пектинов // Эфферентная терапия. 2001. Т. 7, № 4. С. 22-36.
5. Якубовская Р.И. Современные представления о молекулярных механизмах канцерогенеза и опухолевой прогрессии как основа для разработки новых методов терапии злокачественных новообразований // Российский онкологический журнал. 2000. № 6. С. 42-50.
6. Bauer H.G., Asp N.-G., Dahlqvist A. et al. Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal β-glucuronidase activity in the rat // Cancer Res. 1981. Vol. 41, No. 6. P. 2518-2523.
7. Оригинальные исследования 36 Тихоокеанский медицинский журнал, 2010, № 2 7. Blumenkrantz S, Asboe-Haunsen G. New method for quantitative determination of uronic acids // Anal. Biochem. 1973. Vol. 54, No. 2. P. 484-489.
8. Freeman H.J., Spiller G.A., Kim Y.S. A double-blind study on the effects of differing purified cellulose and pectin fiber diets on 1,2-dimethylhyldrazine-induced rat colonic neoplasia // Cancer Res. 1980. Vol. 40. P. 2661-2665.
9. Heitman D.W., Hardman W.E., Cameron I.L. Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazineinduced colon carcinogenesis in rat // Carcinogenesis. 1992. Vol. 13, No. 5. P. 815-818.
10. Jackson C.L., Dreaden T.M., Theobald L.K. et al. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure // Glycobiology. 2007. Vol. 17, No. 8. P. 805-819.
11. Jacobs L.R., Lupton J.R. Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets // Cancer Res. 1986. Vol. 46, No. 4. Pt. 1. P. 1727-1734.
12. O'Neill M.A., Ishii T., Albersheim P., Darvill A. Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic polysaccharide // Annu. Rev. Plant Biol. 2004. Vol. 55. P. 109-139.
13. Platt D., Raz A. Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin // J. Natl. Cancer Inst. 1992. Vol. 84, No. 6. P. 438-442.
14. Ridley B.L., O›Neill M.A., Mohnen D. Pectins: structure, biosynthesis, and oligogalacturonide-related signaling // Phytochemistry. 2001. Vol. 57, No. 6. P. 929-967.
15. Watanabe K., Reddy B.S., Weisburger J.H., Kritchevsky D. Effect of dietary alfalfa, pectin and wheat bran on azoxymethaneor methylnitrosourea-induced colon carcinogenesis in F344 rats// J. Natl. Cancer Inst. 1979. Vol. 63, No. 1. P. 141-145.
Review
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, , , , , , , Razina T.G., Zueva E.P., Amosova E.N., Kryilova S.G., Khotimchenko M.Yu., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Yu. Effects of Pectins of Various Molecular Mas On Growth of Ehrlich Adenocarcinoma and Lewis Lung Carcinoma , Cyclophosphan Efficiency in Mice. Pacific Medical Journal. 2010;(2):32-36. (In Russ.)
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