Preview

Pacific Medical Journal

Advanced search

EFFECT OF LAMINARIA JAPONICA-DERIVED FUCOIDAN ON EHRLICH ADENOCARCINOMA AND LEWIS LUNG CARCINOMA, AND EFFICIENCY OF CYCLOPHOSPHANE IN MICE

Abstract

The paper presents study into anti-tumor and antimetastatic
effects of sulphated polysaccharide fucoidan derived
from sea brown algae Laminaria japonica using models of passaged
Ehrlich adenocarcinoma and Lewis lung carcinoma in mice.
The average molecular mass of the specimen under study was 75
kDa. Fucoidan was introduced orally at a dose of 50 and 100 mg/
kg. Fucoidan has had no effect on the growth of Ehrlich adenocarcinoma
and cyclophosphane's efficiency. At a dose of 100 mg/kg
fucoidan had inconsiderable but reliable decrease in mass of primary
tumor of Lewis lung carcinoma, and at both dosages reliably
decreased number of metastatic focuses. Given fucoidan, the antimetastatic
effect of cyclophosphane increased 1.7 to 2.5 times.

About the Authors

Т. Разина
НИИ фармакологии СО РАМН
Russian Federation


Е. Зуева
НИИ фармакологии СО РАМН
Russian Federation


Е. Амосова
НИИ фармакологии СО РАМН
Russian Federation


С. Крылова
НИИ фармакологии СО РАМН
Russian Federation


М. Хотимченко
Владивостокский государственный медицинский университет
Russian Federation


К. Лопатина
НИИ фармакологии СО РАМН
Russian Federation


Л. Ефимова
НИИ фармакологии СО РАМН
Russian Federation


Е. Сафонова
НИИ фармакологии СО РАМН
Russian Federation


О. Рыбалкина
НИИ фармакологии СО РАМН
Russian Federation


T. G. Razina
Research Institute of Pharmacology, SB RAMS
Russian Federation


E. P. Zueva
Research Institute of Pharmacology, SB RAMS
Russian Federation


E. N. Amosova
Research Institute of Pharmacology, SB RAMS
Russian Federation


S. G. Kryilova
Research Institute of Pharmacology, SB RAMS
Russian Federation


M. Yu. Khotimchenko
Vladivostok State Medical University
Russian Federation


K. A. Lopatina
Research Institute of Pharmacology, SB RAMS
Russian Federation


L. A. Efimova
Research Institute of Pharmacology, SB RAMS
Russian Federation


E. A. Safonova
Research Institute of Pharmacology, SB RAMS
Russian Federation


O. Yu. Ryibalkina
Research Institute of Pharmacology, SB RAMS
Russian Federation


References

1. Алексеенко Т.В., Жанаева С.Я., Венедиктова А.А. и др. Противоопухолевая и антиметастатическая активность сульфатированного полисахарида фукоидана, выделенного из бурой водоросли Охотского моря Fucus evanescens // Бюлл. эксперим. биол. мед. 2007. Т. 143, № 6. С. 675-677.

2. Вищук О.С., Ермакова С.П., Фам Дюк Тин и др. Противоопухолевая активность фукоиданов из бурых водорослей // Тихоокеанский медицинский журнал. 2009. № 3. С. 92-95.

3. Bilan M.I., Grachev A.A., Ustuzhanina N.E. Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag. // Carbohydr. Res. 2002. Vol. 337. P. 719-730.

4. Cumashi A., Ushakova N.A., Preobrazhenskaya M.E. et al. A comparative study of the anti-inflammatory, anticoagulany, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds // Glycobiology. 2007. Vol. 17. P. 541-552.

5. Doh-ura K., Kuge T., Uomoto M. et al. Prophylactic effect of dietary seaweed fucoidan against enteral prion infection // Antimicrob. Agents Chemother. 2007. Vol. 51, No. 6. P. 2274-2277.

6. Koyanagi S., Tanigawa N., Nakagawa H. et al. Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities // Biochem. Pharmacol. 2003. Vol. 65, No. 2. P. 173-179.

7. Lee N.Y., Ermakova S.P., Zvyagintseva T.N. et al. Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells // Food Chem. Toxicol. 2008. Vol. 46, No. 5. P. 1793-1800.

8. Li B., Lu F., Wei X., Zhao R. Fucoidan: structure and bioactivity // Molecules. 2008. Vol. 13, No. 8. P. 1671-1695.

9. Patankar M.S., Oehninger S., Barnett T. et al. A revised structure for fucoidan may explain some of its biological activities //J. Biol. Chem. 1993. Vol. 268. P. 21770-21776.

10. Ponce N.M.A., Pujol C.A., Damonte E.B. Fucoida from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies // Carbohydr. Res. 2003. Vol. 338. P. 153-165.

11. Shibata H., Iimuro M., Uchiya N. et al. Preventive effects of Cladosiphon fucoidan against Helicobacter pylori in Mongolian gerbis // Helicobacter. 2003. Vol. 8. P. 59-65.

12. Silva T.M.A., Alves L.G., Queiroz K.C.S. et al. Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora // Braz. J. Biol. Res. 2005. Vol. 38. P. 523-533.

13. Soeda S., Kozako T., Iwata K., Shimeno H. Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells: Its possible mechanism of action // Biochim. Biophys. Acta. 2000. Vol. 1497. P. 127-134.

14. Yamamoto I., Takahashi M., Suzuki T. et al. Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum //Jpn. J. Exp. Med. 1984. Vol. 54, No. 4. P. 143-151.

15. Zhuang C., Itoh H., Mizuno T., Ito H. Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii) // Biosci. Biotechnol. Biochem. 1995. Vol. 59, No. 4. P. 563-567.


Review

For citations:


 ,  ,  ,  ,  ,  ,  ,  ,  , Razina T.G., Zueva E.P., Amosova E.N., Kryilova S.G., Khotimchenko M.Yu., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Yu. EFFECT OF LAMINARIA JAPONICA-DERIVED FUCOIDAN ON EHRLICH ADENOCARCINOMA AND LEWIS LUNG CARCINOMA, AND EFFICIENCY OF CYCLOPHOSPHANE IN MICE. Pacific Medical Journal. 2010;(2):36-39. (In Russ.)

Views: 309


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1609-1175 (Print)