EFFECT OF LAMINARIA JAPONICA-DERIVED FUCOIDAN ON EHRLICH ADENOCARCINOMA AND LEWIS LUNG CARCINOMA, AND EFFICIENCY OF CYCLOPHOSPHANE IN MICE
Abstract
effects of sulphated polysaccharide fucoidan derived
from sea brown algae Laminaria japonica using models of passaged
Ehrlich adenocarcinoma and Lewis lung carcinoma in mice.
The average molecular mass of the specimen under study was 75
kDa. Fucoidan was introduced orally at a dose of 50 and 100 mg/
kg. Fucoidan has had no effect on the growth of Ehrlich adenocarcinoma
and cyclophosphane's efficiency. At a dose of 100 mg/kg
fucoidan had inconsiderable but reliable decrease in mass of primary
tumor of Lewis lung carcinoma, and at both dosages reliably
decreased number of metastatic focuses. Given fucoidan, the antimetastatic
effect of cyclophosphane increased 1.7 to 2.5 times.
About the Authors
Т. РазинаRussian Federation
Е. Зуева
Russian Federation
Е. Амосова
Russian Federation
С. Крылова
Russian Federation
М. Хотимченко
Russian Federation
К. Лопатина
Russian Federation
Л. Ефимова
Russian Federation
Е. Сафонова
Russian Federation
О. Рыбалкина
Russian Federation
T. G. Razina
Russian Federation
E. P. Zueva
Russian Federation
E. N. Amosova
Russian Federation
S. G. Kryilova
Russian Federation
M. Yu. Khotimchenko
Russian Federation
K. A. Lopatina
Russian Federation
L. A. Efimova
Russian Federation
E. A. Safonova
Russian Federation
O. Yu. Ryibalkina
Russian Federation
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Review
For citations:
, , , , , , , , , Razina T.G., Zueva E.P., Amosova E.N., Kryilova S.G., Khotimchenko M.Yu., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Yu. EFFECT OF LAMINARIA JAPONICA-DERIVED FUCOIDAN ON EHRLICH ADENOCARCINOMA AND LEWIS LUNG CARCINOMA, AND EFFICIENCY OF CYCLOPHOSPHANE IN MICE. Pacific Medical Journal. 2010;(2):36-39. (In Russ.)