ИЗУЧЕНИЕ НИТРОКСИДМОДУЛИРУЮЩЕГО ДЕЙСТВИЯ ПРОМЕДОЛА ПРИ ОДНОКРАТНОМ ПРИМЕНЕНИИ ДЛЯ ПРЕДОПЕРАЦИОННОГО ОБЕЗБОЛИВАНИЯ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ
Аннотация
To identify NO-modulating component in the spectrum
of pharmacological effects of opium analgesics, the authors
have conducted investigation into the dynamics of nitric oxide
metabolite content (nitrate/nitrite-ions) in blood serum in patients
with oncologic diseases. Irrespective of men's age and
pathology localization, one-time application of the drug as part
of pre-operative anesthesia resulted in reliable NO-inhibiting
effect. Despite of forming adequate analgesia in women, there
was an activation of nitroxidergic processes, most evident in case
of genital system pathology. The paper discusses mechanisms of
implementation and role of this phenomenon in developing personified
methods of anti-pain therapy.
of pharmacological effects of opium analgesics, the authors
have conducted investigation into the dynamics of nitric oxide
metabolite content (nitrate/nitrite-ions) in blood serum in patients
with oncologic diseases. Irrespective of men's age and
pathology localization, one-time application of the drug as part
of pre-operative anesthesia resulted in reliable NO-inhibiting
effect. Despite of forming adequate analgesia in women, there
was an activation of nitroxidergic processes, most evident in case
of genital system pathology. The paper discusses mechanisms of
implementation and role of this phenomenon in developing personified
methods of anti-pain therapy.
Об авторах
И. В. Дюйзен
Лаборатория фармакологии Института биологии моря им. А.В. Жирмунского ДВО РАН; Владивостокский государственный медицинский университет
Россия
Россия
Н. Е. Ламаш
Лаборатория фармакологии Института биологии моря им. А.В. Жирмунского ДВО РАН; Владивостокский государственный медицинский университет
Россия
Россия
А. А. Денеж
Приморский краевой онкологический диспансер
Россия
Россия
А. С. Фадеева
Приморский краевой онкологический диспансер
Россия
Россия
I. Dyuizen
Laboratory of Pharmacology of Institute of Marine Biology
named after A.V. Zhirmundsky, FEB RAS; Vladivostok State Medical
University
Россия
Россия
N. Lamash
Laboratory of Pharmacology of Institute of Marine Biology
named after A.V. Zhirmundsky, FEB RAS; Vladivostok State Medical
University
Россия
Россия
A. Denezh
Primorsky Regional Oncological Dispensary
Россия
Россия
A. Fadeeva
Primorsky Regional Oncological Dispensary
Россия
Россия
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Для цитирования:
Дюйзен И.В., Ламаш Н.Е., Денеж А.А., Фадеева А.С., ., ., ., . ИЗУЧЕНИЕ НИТРОКСИДМОДУЛИРУЮЩЕГО ДЕЙСТВИЯ ПРОМЕДОЛА ПРИ ОДНОКРАТНОМ ПРИМЕНЕНИИ ДЛЯ ПРЕДОПЕРАЦИОННОГО ОБЕЗБОЛИВАНИЯ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ. Тихоокеанский медицинский журнал. 2010;(2):43-45.
For citation:
., ., ., ., Dyuizen I.V., Lamash N.E., Denezh A.A., Fadeeva A.S. STUDYING NITRIC OXIDE-MODULATING EFFECT OF PROMEDOL DURING SINGLE APPLICATION FOR PRE-OPERATIVE ANESTHESIA OF ONCOLOGICAL PATIENTS. Pacific Medical Journal. 2010;(2):43-45. (In Russ.)
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