Action of prokaryote's deoxiribonucleic acid on humoral and cellular factors of innate and adaptive immunity of of vertebrate animals
Abstract
The paper gives due consideration to the effects of eukaryote's DNA, natural and synthetic oligodeoxynucleotides produced on humoral and cellular factors of innate and adaptive immunity, emphasizing the issues of DNA-Toll-like receptors interaction and innate immunity initiation. Imparting the information about immunostimulating, adjuvant and anti-infectious properties of the prokaryote's DNA, the authors highlight intensification of T-helper factor type-1 immune response that allows promising possibility to apply DNA and oligodeoxynucleotides for the treatment of allergic diseases, including bronchial asthma.
Keywords
УДК612.017.11:577.213/217].08
About the Authors
N. N. Besednova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
T. S. Zaporozhets
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
References
1. Байракова А.Л., Воропаева Е.А., Афанасьев С.С. и др. Роль и биологическое значение толл-подобных рецепторов в антиинфекционной резистентности организма // Вестник РАМН. 2008. № 1. С. 45-54.
2. Биологическая безопасность//Онищенко Г.Г., Пальцев М.А., Зверев В.В. и др. Москва: Медицина, 2006. 304 с.
3. Олишевский С.В., Шляховенко М.А., Козак В.В., Яниш Ю.В. Реакция различных органов иммунной системы на введение бактериальной CpG-ДНК // Экспериментальная онкология. 2005 Т., 27, № 4. С. 50-55.
4. Олишевский С.В., Козак В.В., Яниш Ю.В. и др. Иммуностимулирующая CpG-ДНК перспективы клинического применения в онкологии // Онкология. 2006. Т 8, № 2. С. 209-217.
5. Пак В.Г., Олиферук Н.С., Будихина А.С., Пинегин Б.В. Влияние естественных и синтетических CpG-мотивов на бактерицидность, NK-литическую активность, индукции. ИЛ-12 и ИФНγ in vitro//Иммунология. 2005. № 6 С. 332-335
6. Серебряная Н.Б., Калинина Н.М. Иммуномодулирующая активность и эффективность использования в терапии воспалительных заболеваний препаратов нативной ДНК- дерината и ферровира//Иммунитет и болезни: от теории к терапии: мат. междунар. конгресса. М., 2005. С. 58-59.
7. Хаитов P.M., Игнатьева Г.А. Сидорович И.Г. Иммунология. М.: Медицина, 2002. 536 с.
8. Adamson J., Lindblad M., Lundqvist A. et al. Novel immunostimulatory agent based on CpG ODN linked to the nontoxic В subunit of cholera toxin// J. Immunol. 2006. V. 176, No. 8. P. 4902-4913.
9. Avia J., Igal L., Plis-Finarov A. et al. Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis В vaccines // Vaccine. 2002. Vol. 20, No. 27-28 P. 3342-3354
10. Ballas Z.K. Modulation of NK cell activity by CpG oligodeoxynucleotides// Immunologic Research. 2007. Vol. 39, No. 1-3. P. 15-21.
11. Bendigs S., Salzer U., Lipford G.B. et al. CpG-oligodeoxynucleotides со-stimulate primary T cells in the absence of antigen-presenting cells // Europ. J. Immunology. 1999. Vol. 29, No. 4. P. 1209-1218
12. Chu R.S., Askew D., Noss E.N. et al. CpGoligodeoxynucleotides downregulate macrophage class II MHC antigen processing///. Immunology. 1999. Vol. 163. P. 1188-1194.
13. Dalpke A.H., Schafer M.K-H, Frey M. et al. Immunostimulatory CpG-DNA Activaties Murine Microglia// The J. of Immunology. 2002. Vol. 168. P. 4854-4863.
14. Du H, Xia Sh., Song H.et al. Structure efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells // Acta Pharmacologica Sinica. 2007. Vol. 20, No. 10. P. 1637-1644.
15. Flaminio M.J., Borges A.S., Nydam D.V. et al. The effect of CpG-ODN on antigen presenting cells of the foal // J. Immune Based Ther. Vaccines. 2007. No. 5 P. 18-23.
16. Gupta K.,Cooper C. A Reviev of the Role of CpG Oligodeoxynucleotides as Toll-like Receptor 9 Agonist in Prophylactic and Therapeutic Vaccine Development in infectious Diseases // Drugs in Rand D. 2008. Vol. 9, No. 3 P. 137-145.
17. Hackett C.J. Innate immune activation as a broad-spectrum biodefence strategy: prospects and research challenges // J. Allergy Clin. Immunol. 2003. Vol. 112. P. 686-694.
18. Jahrsdorfer В., Weiner G. CpG oligodeoxynucleotides as immunotherapy in cancer// Cancer Therapeutics. 2006. Vol. 3, No. 1. P. 27-32.
19. Jacob T., Walker P.S., Krieg A.M. et al. Activation of cutaneous dendritic cells by CpG-containing ODN of TH1 responses by immu-nostimulatory DNA//J. Immunol. 1998 Vol. 161. P. 3042-3049
20. Jozsef I., Khreiss T., Filep J.G. CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes // Faseb J. 2004. Vol. 18 P. 1776-1778
21. Kensuke M. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors // Sem. Immunol. 2007. Vol. 19. P. 3-10.
22. Kline J.N., Krieg A.M. Toll-like receptor 9 activation with CpG ODN for asthma therapy // Drug News Perspect. 2008. Vol. 21, No. 8. P. 434-439.
23. Klinman D., Shirota H., Tross D. et al. Synthetic ODN as modulator of inflammation//J. of leucocyte Biol. 2008 Vol. 84. P. 958-964
24. Krieg A.M. Antiinfective Application of Toll-like Receptor 9 Agonist// The proceedings of the American Thoracis Society. 2007. Vol. 4 P. 289-294.
25. Maletto В., Ropolo A., Moron V., Pistoresi - Palencia M.C CpG-DNA stimulates cellular and humoral immunity and promotes Th 1 differentiation in aged Balb/c mice // Journ. of leucocyte Biology. 2002. Vol. 72. P. 447-454.
26. Park Y., Lee S.W., Sung Y.C. Cutting Edge: CpG-DNA inhibits dendritic cell apoptosis by up-regulation cellular inhibitor of apoptosis proteins, through the Phosphatidylinositide-3-OH kinase pathway // J. Immunology. 2002. Vol.1, No. 168. P. 5-8.
27. Silverman E.S., Drazen J.M. Immunostimulatory DNA for Asthma//Am. J. Respir. Cell. Mol. Biol. 2003. Vol. 28. P. 645-647.
28. Sparwasser Т., Hultner I., Koch E.S. Immunostimulatory CpG-ODN cause extramedullar murine hemopoesis // J. Immunology. 1999. Vol. 162. P. 2368-2374
29. Tocunaga T., Yamamoto H., Shimada S. et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG//J Nat. Cancer Inst. 1984. Vol. 72, No. 4. P. 955-962
30. Yoshinaga T., Yasuda K., Ogawa Y. et al. DNA and its cationic lipid complexes induce CpG-motif-dependent activation of murine dendritic cells//Immunology. 2007. Vol. 120, No. 3. P. 295-302
31. Verthelyi D., Klinman D.M. Immunoregulatory activity of CpG-ODN in humans and nonhuman primates // Clin. Immunol. 2003. Vol. 109. P. 64-71.
32. Wang H., Rayburn E., Zhang R. Synthetic ODN cjntaining deoxycytidyl-deoxyguanosine dinucleotides (CpG-ODNs) and modified analogs as novel anticancer therapeutics // Curr Pharm. Des. 2005. Vol. 11, No. 22. P. 2889-2997.
33. Wen-Ming-Chu.,Dragoi A.M., Cong Cao, Wan Y. Mechanism of cell survival induced by CpG-DNA // The FASEB J. 2008. Vol.22. P. 672-675
Review
For citations:
Besednova N.N., Zaporozhets T.S. Action of prokaryote's deoxiribonucleic acid on humoral and cellular factors of innate and adaptive immunity of of vertebrate animals. Pacific Medical Journal. 2009;(3):8-12. (In Russ.)
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