Immunoadjuvant effect of cytokines
Abstract
The paper gives consideration to the adjuvant properties of cytokines studied by using experimental models. They induced immunogenic activities by means of rabies vaccine. Combined with a complex of recombinant cytokines, the vaccine exhibited the most noticeable effects. Augmenting immune response was observed in parallel to high-level virus neutralizing antibody formation. The immunoadjuvant effects were observed when using recombinant interleukin-lb and tumor necrosis factor-α for monodrug therapy and "Polyoxidonium". The research results were indicative of the possibility to apply cytokines and other immune-response modulating drugs as adjuvants capable of increasing immunogenic activities of the vaccines and highlight promising opportunities of researching into new approaches to immune response control.
About the Authors
Zh. L. Avdeeva
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations
Russian Federation
Russian Federation
N. A. Alpatova
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations
Russian Federation
Russian Federation
S. E. Akolzina
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations
Russian Federation
Russian Federation
N. V. Medunitsin
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations
Russian Federation
Russian Federation
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Review
For citations:
Avdeeva Zh.L., Alpatova N.A., Akolzina S.E., Medunitsin N.V. Immunoadjuvant effect of cytokines. Pacific Medical Journal. 2009;(3):19-22. (In Russ.)
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