Study on immune-response modulating and membrane-acting effects of carotenoids derived from the tunic of Ascidia halocynthia aurantium
Abstract
The paper discusses immune-response modulating and membrane-acting effects of carotenoids derived from the Halocynthia aurantium ascidia tunic and gives consideration to 12 components, among which xanthophylls are dominant. These are: astaxanthin, alloxantin, diatoxanthine, halocynthi-axanthine, fucoxanthinol, and methylxanthine. Halocynthiax-anthine is peculiar to this form and used to identify halocynthi-axanthine-based drugs. Original patented method has allowed to derive oily extract from the ascidian tunic registered as dietary supplement. As shown, this medication induces bactericidal and phagocytic activities of neutrophils, antioxygenic properties of blood serum, inhibits peroxidation, and produces anti-inflammatory and hemostimulating effects. The ascidian tunic carotenoids have membrane-acting properties and capability to be bound together with phospholipids and stabilize membrane structure. The findings allow recommending the dietary supplement "Ascidian-Derived Oily Extract" for advanced clinical testing.
Keywords
УДК615.37:[615.324:596.2]
About the Authors
E. S. Motorya
TINRO-Centre
Russian Federation
Russian Federation
T. N. Pivnenko
TINRO-Centre
Russian Federation
Russian Federation
A. S. Gazha
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
L. A. Lvanushko
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
V. N. Vorontsov
Far Eastern National University
Russian Federation
Russian Federation
N. M. Sanina
Far Eastern National University
Russian Federation
Russian Federation
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Review
For citations:
Motorya E.S., Pivnenko T.N., Gazha A.S., Lvanushko L.A., Vorontsov V.N., Sanina N.M. Study on immune-response modulating and membrane-acting effects of carotenoids derived from the tunic of Ascidia halocynthia aurantium. Pacific Medical Journal. 2009;(3):28-32. (In Russ.)
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