Sulphated polysaccharides derived from sea brown algae as inducing substances for dendritic cell matu-ration
Abstract
The paper presents experimental study into the effects of sulphated polysaccharides - fucoidans derived from the sea brown algae Laminaria cichorioides and Laminaria japonica on maturation of dendritic cells extracted from the mice bone marrow. As reported, the fucoidans tend to induce expression of terminal differentiation markers, intensify activation marker, adhesion molecules, surface antigen-presenting and bone marrow inducing molecules, as well as Toll-like receptors on the dendritic cell membranes that appears to be indicative of their maturation.
Keywords
УДК611.018.83:615.37:[615.322:582.272.46]:577.114
About the Authors
I. D. Makarenkova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
N. K. Akhmatova
I.I. Mechnikov Research Institute of Vaccines and Serums, RAMS
Russian Federation
Russian Federation
I. B. Semenova
I.I. Mechnikov Research Institute of Vaccines and Serums, RAMS
Russian Federation
Russian Federation
N. N. Besednova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
T. N. Zvyagintseva
Pacific Institute of Bioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Makarenkova I.D., Akhmatova N.K., Semenova I.B., Besednova N.N., Zvyagintseva T.N. Sulphated polysaccharides derived from sea brown algae as inducing substances for dendritic cell matu-ration. Pacific Medical Journal. 2009;(3):36-39. (In Russ.)
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