Antiviral activity of combined medication Zostera asiatica-derived rosmarinic acid against tick-borne encephalitis pathogen
Abstract
Experimental tick-borne encephalitis models allowed in vivo and in vitro researches into combined medication Zostera asiatica-derived rosmarinic acid created on the basis of plant polyphenol compound of rosmarinic acid and bioflavonoids (luteolin, apigenin, etc.). As shown, when introduced orally (the most efficient mode of administration) this medication increased survival rate of mice infected with highly pathogenic strain of the tick-born encephalitis virus and prolonged their life. It did not cause a pig embryo kidney cell culture destruction and suppressed viral infection activity.
Keywords
УДК [616.831-002-022:578.833]-085.281.322:582.26/27
About the Authors
N. V. Kryilova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
G. N. Leonova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
A. M. Popov
Pacific Institute ofBioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
A. A. Artyukov
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
O. S. Maistrovskaya
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
E. P. Kozlovskaya
Pacific Institute ofBioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Kryilova N.V., Leonova G.N., Popov A.M., Artyukov A.A., Maistrovskaya O.S., Kozlovskaya E.P. Antiviral activity of combined medication Zostera asiatica-derived rosmarinic acid against tick-borne encephalitis pathogen. Pacific Medical Journal. 2009;(3):86-88. (In Russ.)
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