Protective effects of fucoidan derived from brown algae Laminaria japonica under experimental tick-borne encephalitis
Abstract
The paper provides experimental study into the protective effects of sulphated polysaccharide fucoidan derived from the sea brown algae Laminaria japonica after in vivo infecting mice with highly pathogenic strain of tick-borne encephalitis virus. As reported, the drug efficiency depends on dose and dosing regimen, and it allows obtaining adequate protection in infected animals. A wide range of biological effects produced by the sulphated polysaccharides extracted from the sea brown algae, low toxicity and environmentally friendly production technologies offer great opportunities of applying fucoidans in an effort to prevent and treat viral infections.
Keywords
УДК[616.831-002-022:578.833]-085.322:582.272:577.114
About the Authors
I. D. Makarenkova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
N. V. Kryilova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
G. N. Leonova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
N. N. Besednova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
T. N. Zvyagintseva
Pacific Institute of Bioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
N. M. Shevchenko
Pacific Institute of Bioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Makarenkova I.D., Kryilova N.V., Leonova G.N., Besednova N.N., Zvyagintseva T.N., Shevchenko N.M. Protective effects of fucoidan derived from brown algae Laminaria japonica under experimental tick-borne encephalitis. Pacific Medical Journal. 2009;(3):89-92. (In Russ.)
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