Anticancer activity of brown algae-derived fucoidans
Abstract
The authors have studied anticancer activities of fucoidans derived from nine brown algae species using the soft agar-agar model. As shown, the fucoidans are non-toxic to DLD-1 and HT-29 cells in concentrations of up to 200 μg/mL. The fucoidan extracted from Laminaria cichorioides and composed of 1.3-tie molecules alpha-L-fucose tends to inhibit growth of cancer cell colonies in bowels. The low sulphated fucogalactans derived from Sargassum swartzii, S. mcClurei and S. denticarpum do not really exhibit anticancer properties. The findings allowed considering application of the brown algae-derived fucoidans (Far Eastern seas) as very promising in effort to prevent and treat oncological diseases.
About the Authors
O. S. Vischuk
Far Eastern National University
Russian Federation
Russian Federation
S. P. Ermakova
Pacific Institute ofBioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
Fam Dyuk Tin
Nha Trang Institute of Technological Studies and VANT Application
Russian Federation
Russian Federation
N. M. Shevchenko
Pacific Institute ofBioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
Bui Ming Li
Nha Trang Institute of Technological Studies and VANT Application
Russian Federation
Russian Federation
T. N. Zvyagintseva
Pacific Institute ofBioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Vischuk O.S., Ermakova S.P., Fam Dyuk Tin , Shevchenko N.M., Bui Ming Li , Zvyagintseva T.N. Anticancer activity of brown algae-derived fucoidans. Pacific Medical Journal. 2009;(3):92-95. (In Russ.)
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