Local and system immune response in case of community-acquired pneumonia in young patients
Abstract
The examinations of 216 patients with community-acquired pneumonia allowed estimating receptor activity of immunocytes contained in peripheral blood, induced sputum and mucous tunic of large bronchi. Homogenous antibodies were used for cell differentiation. The acute phase of the disease leaded to a decreasing number of cells CD3+, CD4+, CD8+ and CD25+ contained in peripheral blood. There was a decreasing number of cells CDllb+, CD18+, CD4+, CD16+, CD25+, and HLA-DR+ found in induced sputum. The recovery period was characterized by decreasing number of cells CD3+ contained in blood. Low number of immunocytes was observed in populations CD3+, CD4+, CD8+, CD25+ and HLA-DR+ during the follow-up period. The quantity of cells CD4+, CD25+, CD16+, CD22+, CDllb+, CD18+ and HLA-DR+ found in the induced sputum after 20-day and 6-month periods did not reach control values. The followup period was characterized by increasing values of CDllb+-cells found in mucous tunic of large bronchi. No reliable differences were observed between the indices of various biological environments.
About the Authors
V. A. Nevzorova
Vladivostok State Medical University
Russian Federation
Russian Federation
T. F. Borovskaya
Khabarovsk branch of RORC named after N.N. Blokhin RAMS
Russian Federation
Russian Federation
Т. В. Dmitrieva
Yuzhno-Sakhalinsk Municipal Hospital named after F. S. Ankudinov
Russian Federation
Russian Federation
L. D. Skrebkova
Yuzhno-Sakhalinsk Municipal Hospital named after F. S. Ankudinov
Russian Federation
Russian Federation
S. A. Pazyich
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Nevzorova V.A., Borovskaya T.F., Dmitrieva Т.В., Skrebkova L.D., Pazyich S.A. Local and system immune response in case of community-acquired pneumonia in young patients. Pacific Medical Journal. 2009;(3):106-109. (In Russ.)
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