Role of T-cell dysfunction in the development of lower limb atherosclerosis and treatment opportunities
Abstract
Forty clinical observations performed by authors allowed studying the role of T-cell dysfunctions in the development of lower limb atherosclerosis and finding out that peripheral lymphocyte subpopulation indices were within the value range indicating satisfactory immune system functions. Increasing number of circulating lymphocytes and intensified expression of interleukin-2 receptor, class II major histocompatibility antigens and apoptosis marker on the lymphocyte surface indicated that the T-cell activation was not restricted to the atherosclerotic plaque area. The parameters which characterized relation of lymphocyte subpopulations and intensity of activation processes confirmed participation of activated T- lymphocytes in the pathogenesis of atherosclerosis. As reported, biological dietary supplement "Fucolam" created on the basis of the Fucus evanescens brown algae fucoidan exhibited corrective effect on the intensity of inflammatory process in patients with lower limb atherosclerosis.
Keywords
УДК616.137-004.6-085.232:582.272.46
About the Authors
T. S. Zaporozhets
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
К. V. Maistrovskiy
Vladivostok State Medical University
Russian Federation
Russian Federation
V. G. Rapovka
Vladivostok State Medical University
Russian Federation
Russian Federation
A. K. Gazha
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
Т. Р. Smolina
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
T. N. Zvyagintseva
Pacific Institute ofBioorganic Chemistry, FE RAS
Russian Federation
Russian Federation
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Review
For citations:
Zaporozhets T.S., Maistrovskiy К.V., Rapovka V.G., Gazha A.K., Smolina Т.Р., Zvyagintseva T.N. Role of T-cell dysfunction in the development of lower limb atherosclerosis and treatment opportunities. Pacific Medical Journal. 2009;(3):110-115. (In Russ.)
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