Role of hypoxemia in forming immune disorders and haemostasis in patients with chronic obstructive pulmonary disease
Abstract
The authors have examined two groups of patients with chronic obstructive pulmonary disease (24 patients without hypoxemia and 17 patients with hypoxemia) and revealed interdependence between hypoxemia level and system inflammation and haemosta-sis. The levels of systemic inflammation markers, hypercoagulation and fibrinolytic system suppression in patients with hypoxemia was considerably higher than those of the patients with normal parameters of the arterial blood oxygen saturation that was indicative of a considerable role of hypoxemia in pathogenesis of inflammatory reaction in case of chronic obstructive pulmonary disease.
Keywords
УДК616.24-033.3-036.12-06:612.017.1
About the Authors
M. F. Kinyaikin
Vladivostok State Medical University
Russian Federation
Russian Federation
G. I. Sukhanova
Vladivostok State Medical University
Russian Federation
Russian Federation
I. V. Naumova
Vladivostok State Medical University
Russian Federation
Russian Federation
Т. А. Kuznetsova
Research Centre of Epidemiology and Microbiology of the RAMS, Siberian Branch
Russian Federation
Russian Federation
A. Ya. Ovchinnikov
Vladivostok State Medical University
Russian Federation
Russian Federation
I. M. Poletaeva
Vladivostok State Medical University
Russian Federation
Russian Federation
V. M. Beznis
Vladivostok State Medical University
Russian Federation
Russian Federation
References
1. Авдеев С.Н. Хроническая обструктивная болезнь легких как системное заболевание // Хроническая обструктивная болезнь легких. М.: Атмосфера, 2008. С.131-149.
2. Баркаган З.С., Момот А.П. Диагностика и контролируемая терапия нарушений гемостаза. М.: Ньюдиамед, 2001. 286 с.
3. Киняйкин М.Ф., Суханова Г.И., Удовиченко И.А., Кондрашова Е.А. Миокардиальные повреждения у больных хронической обструктивной болезнью легких // Пульмонология. 2008. № 5. С.7 1-74.
4. Киняйкин М.Ф. Состояние гемостаза у больных хроническим обструктивным бронхитом в процессе формирования хронического легочного сердца // X Национальный конгресс по болезням органов дыхания: сб. резюме. СПб., 2000. С. 333.
5. Кузнецова Т.А., Киняйкин М.Ф., Буякова Е.Д. и др. Динамика гуморальных факторов естественной резистентности у больных хроническими обструктивными болезнями легких под влиянием иммунокоррекции // Цитокины и воспаление. 2007. № 4. С.59-62
6. Gan W.Q., Man S.F., Senthilselvan A., Sin D.D. The association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis// Thorax. 2004. Vol. 59. P. 574-580
7. Global Initiative for Chronic Obstructive Lung Disease (GOID) NHIBI/WHO workshop report. Last updated 2006. URI: http://www.goldcopd . org.
8. Joppa P., Petrasova D., Stancak В., Tkacova R. Systemic inflammation inpatients with COPD) and pulmonary hypertension //Chest. 2006. Vol. 130. P. 326-333.
9. Keer R., Stirling D., ludlam C.A. Interleukin-6and haemostasis//Br. J. Haematol. 2001. Vol. 115, No. 1. P. 586-592.
10. Levi M., TenCate H. Disseminated intravascular coagulation// N. Engl. J. Med. 1999 Vol. 341, No. 8 P. 586-592
11. Naeije R. Pulmonary hypertension and right heart failure in COPD//Monaldi Arch. Chest. Dis. 2003 Vol. 59. P. 250-253.
12. Von Euler U., Lijestrand G. Observations on the pulmonary arterial blood pressure in cat//Acta Physiol. Scand. 1946. Vol.12. P. 301-320.
13. Zielinski J., Mac Nee W., Wedzicha J. et al. Causes of death in patients with COPD and chronic respiratory failure. Monaldi Arch. Chest Dis. 1997 Vol. 52. P. 43-47.
Review
For citations:
Kinyaikin M.F., Sukhanova G.I., Naumova I.V., Kuznetsova Т.А., Ovchinnikov A.Ya., Poletaeva I.M., Beznis V.M. Role of hypoxemia in forming immune disorders and haemostasis in patients with chronic obstructive pulmonary disease. Pacific Medical Journal. 2009;(3):120-122. (In Russ.)
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