Endothelial and immune dysfunctions during early perioperative period in patients with lower limb injuries

Abstract

The authors have studied adequacy and role of analgesia in developing endothelial and immune dysfunctions during the early peri-operative period with respect to 20 patients aged 40 to 60 with serious lower limb injuries. As shown, there were cellular and humoral dysfunctions of innate and adaptive immunity in the form of depression. These were observed by the moment of surgical treatment at the background of endothelial dysfunction. Lacking significant differences in the parameters indicating the state of immune system and endothelium in the dynamics of the early peri-operative period were indicative of an adequate character of anaesthesia. The analgesic of peripheral action (ke-toprofen) was combined with opioids (promedol) and allowed to maintain postoperative homeostasis and balance between pro-and anti-inflammatory potentials of immunocompetent cells, thus preventing extended stress response to the surgery.