HIV infection associated with tuberculosis in Primorskiy Krai: detection, clinical course and immune mechanisms of pathogenesis
Abstract
The paper provides results of regular medical checkup of 106 patients with HIV infection associated with tuberculosis and gives consideration to epidemiological, clinical and laboratory data as well as immunological examinations conducted at various stages of the disease. The studies allowed revealing T-cell immunodeficiency at all the HIV infection stages and close negative correlation between the HIV load level and absolute T-lymphocyte content (including T-helpers) at IVB and V stages. There was considerable increase in proinflammatory cytokine level. The hypocytokinemia correlated with the severity of the persistent infection. As far as the disease aggravated, there was differently directed character of dynamics of immunoglobulin level.
About the Authors
S. A. Sotnichenko
Regional Clinical Centre of Prevention and Fight against AIDS
Russian Federation
Russian Federation
E. V. Markelova
Regional Clinical Centre of Prevention and Fight against AIDS
Russian Federation
Russian Federation
L. F. Sklyar
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Sotnichenko S.A., Markelova E.V., Sklyar L.F. HIV infection associated with tuberculosis in Primorskiy Krai: detection, clinical course and immune mechanisms of pathogenesis. Pacific Medical Journal. 2009;(3):133-136. (In Russ.)
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