Antibiotic-resistant forms of pathogenic microflora in patients with surgical sepsis

Abstract

Background. In developed countries, the incidence of sepsis is 200-275 cases per 100,000 of population. Annualy in the United States it is recorded up to 500,000 cases of sepsis with a mortality rate of 20-50 %. Methods. It was conducted a retrospective analysis of 363 cases of patients with surgical infections, who had been hospitalized to the City Clinical Hospital and to the Amur Regional Clinical Hospital, Blagoveshchensk in the 1985-2014. Results. It was revealed the etiological role of gram-negative bacteria in patients with surgical sepsis. The role of microbial associations (Escherichia coli with Staphylococcus aureus, Staphylococcus epidermidis, and with bacteria of the genus Proteus) increased. The proportion of Pseudomonas aeruginosa increased among the sepsis pathogens (1.4 times) and fungi of the genus Candida (1.6 times). The number of mixed infections increased (up 16.9 %). Conclusions. The bacterial component in the etiology of surgical sepsis nowadays is characterized by a predominance of gram-negative bacteria, increasing of the frequency of microbial associations and fungi of the genus Candida, the predominant sensitivity of pathogens to drugs of carbapenems group (meropenem, imipenem, doripenem) and cephalosporins of III-IV generation (cefoperazone, cefepime, cefpirome, cefotaxime).