The use of the biochemical and immunologic markers at the monitoring of the postoperative pain
Abstract
Till now there are no authentic diagnostic biochemical and immunologic markers used for the estimation of a pain syndrome, the pain remains subjective sensation. We studied the features of change of the some molecules-bioregulators in blood at patients, who underwent abdominal surgery, in case of acute pain and at stages of the early postoperative period at various analgesics. It is shown, that postoperative pain reaction is accompanied by increase in blood of a level of the nitrogen oxide metabolites, the products of the lipid peroxidation, some cytokines — the tumor necrosis factor A, IL 1 and 8 and CD95+ cells. There were no authentic distinctions of efficiency at traditional analgesia with narcotic analgesics and combined analgesia (Promedol and Ketoprophen), allowing to reduce the amount of a used narcotics.
About the Authors
V. B. Shumatov
Vladivostok state medical university
Russian Federation
Russian Federation
S. P. Kryzhanovskiy
Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Science
Russian Federation
Vladivostok
Russian Federation
Vladivostok
N. A. Andreeva
Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Science
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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Review
For citations:
Shumatov V.B., Kryzhanovskiy S.P., Andreeva N.A. The use of the biochemical and immunologic markers at the monitoring of the postoperative pain. Pacific Medical Journal. 2008;(1):27-29. (In Russ.)
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