Prophilactic effect of calcium alginate in case of indomethacin-induced injuries of mucous coat of rat's stomach
Abstract
The authors have used the model of indomethacine‑induced injuries of rat’s stomach to assess gastroprotective action of calcium alginate, and revealed that preliminary intragastric introduction of calcium alginate hampers the formation of destructive injuries of mucous coat of stomach. The authors believe their findings allow to consider calcium alginate as drug intended to prevent ulcer‑related injury caused by nonsteroidal antiinflammatory drugs.
About the Authors
M. Yu. Khotimchenko
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
T. G. Razina
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
N. V. Shilova
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
E. N. Amosova
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
S. G. Krylova
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
K. A. Lopatina
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
Yu. S. Khotimchenko
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
E. P. Zueva
Vladivostok State Medical University;
SBRAMS (Tomsk Research Center) Research Institute of Pharmacology;
FEBRAS Institute of Marine Biology
Russian Federation
Russian Federation
Tomsk;
Vladivostok
References
1. Хотимченко Ю.С., Ковалев В.В., Савченко О.В., Зиганшина О.А. // Биология моря. – 2001. – Т. 27, № 3. – С. 151–162.
2. Chan F.K., Graham D.Y. // Aliment. Pharmacol. Ther. – 2004. – Vol. 19. – P. 1051–1061.
3. Del Valle. J., Chey W.D., Scheiman J.M. // Textbook of Gastroenterology ; 4th ed. / eds. T. Yamada, D.H. Alpers, N. Kaplowitz. – Philadelphia : Lippincott Williams & Wilkins, 2003. – P. 1321–1376.
4. Elliott S.L., Ferris R.J., Giraud A.S. et al. // Clin. Exp. Pharmacol. Physiol. – 1996. – Vol. 23. – P. 432–434.
5. Ferrucci F., Zucca E., Croci C. et al. // Vet. Res. – 2003. – Vol. 152. – P. 679–681.
6. Garcia Rodriges L.A., Hernandez-Diaz S. // Am. J. Epidemiol. – 2004. – Vol. 159. – P. 23–31.
7. Hawkey C.J., Karrasch J.A., Szczepanski L. et al. // New Engl. J. Med. – 1998. – Vol. 338. – P. 727–734.
8. Khotimchenko Y.S., Khotimchenko M.Y. // Marine Drugs. – 2004. – Vol. 2. – Р. 108–122.
9. Levine L. // Prostaglandins Leukot // Essent. Fatty Acids. – 2001. – Vol. 65. – P. 31–35.
10. Lim C.H., Heatley R.V. // Postgrad. Med. J. – 2005. – Vol. 81. – P. 252–254.
11. Reeves J.J., Stables R. // Br. J. Pharmacol. – 1985. – Vol. 86. – P. 677–684.
12. Rifat-uz-Zaman, Akhtar M.S., Khan M.S. // Intl. J. Pharmacol. – 2006. – Vol. 2. – P. 166–170.
13. Trommer H., Neubert R.H. // Int J. Pharm. – 2005. – Vol. 298. – P. 153–163.
14. Yeomans N.D., Tulassay Z., Juhasz L. // N. Engl. J. Med. – 1998. – Vol. 338. – P. 719–726.
15. Yoshikawa T., Naito Y., Nakamura S., Kaneko T. // Arzneim-Forsch / Drug Res. – 1993. – Vol. 43. – P. 1327–1330.
Review
For citations:
Khotimchenko M.Yu., Razina T.G., Shilova N.V., Amosova E.N., Krylova S.G., Lopatina K.A., Khotimchenko Yu.S., Zueva E.P. Prophilactic effect of calcium alginate in case of indomethacin-induced injuries of mucous coat of rat's stomach. Pacific Medical Journal. 2007;(4):42-44. (In Russ.)
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