Nitric oxide-generating activity of neutrophils in case of pseudotuberculous and listerious infections
Abstract
The authors studied nitric oxide‑generating activity of neutrophils of various biological models infected in vitro with Y. pseudotuberculosis and L. monocytogenes, and revealed differences in nitric oxide production, depending on physiological state of neutrophils and type of bacteria. In case of cell adhesion, the authors observed increasing intracellular content of nitric oxide metabolites in human neutrophils and noninflammatory animals’ exudates (guinea pigs and mice). The neutrophils found in inflammatory exudates responded contrariwise. In response to infection with Y. pseudotuberculosis, the nitric oxide‑dependent bactericidal set of cells exhibited a high‑grade sensitivity, as compared to that with L. monocytogenes.
About the Authors
N. G. Plekhova
SBRAMS Research Institute of Epidemiology and Microbiology
Russian Federation
Vladivostok
Russian Federation
Vladivostok
S. V. Okhotina
SBRAMS Research Institute of Epidemiology and Microbiology
Russian Federation
Vladivostok
Russian Federation
Vladivostok
E. I. Drobot
SBRAMS Research Institute of Epidemiology and Microbiology
Russian Federation
Vladivostok
Russian Federation
Vladivostok
L. M. Somova
SBRAMS Research Institute of Epidemiology and Microbiology
Russian Federation
Vladivostok
Russian Federation
Vladivostok
References
1. Реутов В.П., Сорокина Е.Г., Охотин В.Е., Косицын Н.С. Циклические превращения оксида азота в организме млекопитающих. – М. : Наука, 1997.
2. Albina J.E. // J. Leukocyt. Biol. – 1995. – Vol. 58. – P. 643–649.
3. Andonegui G., Trevani A.S., Gamberale R.et al. // J. Immunol. – 1999. – Vol. 162. – P. 2922–2930.
4. Beckmann J.S., Koppenol W.H. // Am. J. Phisiol. – 1996. – Vol. 271. – P. C. 1424–C1437.
5. Bryant J.L., Mehta P., Vonderporten A., Mehta J.L. // Biochem. Biophys. Res. Commun. – 1992. – Vol. 189. – P. 558–563.
6. Evans T.J., Buttery L.D.K., Carpenter A. et al. // Proc. Natl. Acad. Sci. USA. – 1996. – Vol. 93, No. 18. – P. 9553–9558.
7. Fang F.C. // J. Clin. Invest. – 1997. – Vol. 99, No. 12. – P. 2818–2825.
8. Hope B.T., Vinsent S.R. // J. Histochem. Cytochem. – 1989. – Vol. 37. – P. 653–661.
9. Klebanoff S.J., Nathan C.F. // J. Leukoc. Biol. – 1993. – Vol. 197, No. 1. – P. 192–196.
10. Miles A.M., Owens M.W., Milligan S. et al. // J. Clin. Invest. – 1992. – Vol. 90, No. 2. – P. 631–636.
11. Nathan C., Shiloh M. // Proc. Natl. Acad. Sci. USA. – 2000. – Vol. 97, No. 16. – P. 8841–8848.
12. Schulz K., Kerber S., Kelm M. // J. Nitric Oxide. – 1999. – Vol. 3, No. 3. – Р. 225–234.
13. Wheeler M.A., Smith S.D., Garcia-Cardena G. et al. // J. Clin. Invest. – 1997. – Vol. 99. – P. 110–116.
14. Wright C.D., Mulsch A., Busse R., Osswald H. // Biochem. Biophys. Res. Commun. – 1989. – Vol. 160, No. 2. – P. 813–819.
Review
For citations:
Plekhova N.G., Okhotina S.V., Drobot E.I., Somova L.M. Nitric oxide-generating activity of neutrophils in case of pseudotuberculous and listerious infections. Pacific Medical Journal. 2007;(4):47-50. (In Russ.)
Views:
228
Email this article 