OPPORTUNITY OF USE OF DNA FROM THE SALMON SPERM AT THE PSEUDO-TUBERCULOSIS
Abstract
The action of low-molecular DNA from salmon sperm and the drinks enriched with this substance is investigated, at experimental pseudo-tuberculosis. At prophylactic feeding of the animals by lDNA and drinks, containing it, the survival rate of mice at infection of them with 100% lethal doze of bacteria raised. DNA stimulated the functional activity of peritoneal neutrophil cells and prevented the lethal action of the thermos resistant toxin of Y. рseudo-tuberculоsis. The use of DNA resulted in correction of pathogenic influence of the thermo resistant lethal toxin on oxidizing and antioxidizing enzyme systems of mice’s neutrophil cells.
About the Authors
N. F. Timchenko
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
S. N. Pavlinich
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
V. K. Pokrovsky
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
L. S. Dolmatova
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
T. A. Kuznetsova
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
T. K. Kalenik
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
L. M. Epshteyn
Scientific Research Institute of Epidemiology and microbiology Siberian Branch of the RAMS;
Pacific State Economic University;
Pacific Oceanologic Institute named by V.I.Il’yichev Far-Eastern Branch of the Russian Academy of Science;
Pacific Research Fishfarming Center
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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Review
For citations:
Timchenko N.F., Pavlinich S.N., Pokrovsky V.K., Dolmatova L.S., Kuznetsova T.A., Kalenik T.K., Epshteyn L.M. OPPORTUNITY OF USE OF DNA FROM THE SALMON SPERM AT THE PSEUDO-TUBERCULOSIS. Pacific Medical Journal. 2006;(4):80-82. (In Russ.)
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